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2-Oxabicyclo[2.2.2]octane as a new bioisostere of the phenyl ring.
Levterov VV, Panasiuk Y, Sahun K, Stashkevych O, Badlo V, Shablykin O, Sadkova I, Bortnichuk L, Klymenko-Ulianov O, Holota Y, Lachmann L, Borysko P, Horbatok K, Bodenchuk I, Bas Y, Dudenko D, Mykhailiuk PK. Levterov VV, et al. Among authors: shablykin o. Nat Commun. 2023 Oct 2;14(1):5608. doi: 10.1038/s41467-023-41298-3. Nat Commun. 2023. PMID: 37783681 Free PMC article.
1-Azaspiro[3.3]heptane as a Bioisostere of Piperidine.
Kirichok AA, Tkachuk H, Kozyriev Y, Shablykin O, Datsenko O, Granat D, Yegorova T, Bas YP, Semirenko V, Pishel I, Kubyshkin V, Lesyk D, Klymenko-Ulianov O, Mykhailiuk PK. Kirichok AA, et al. Among authors: shablykin o. Angew Chem Int Ed Engl. 2023 Dec 18;62(51):e202311583. doi: 10.1002/anie.202311583. Epub 2023 Nov 14. Angew Chem Int Ed Engl. 2023. PMID: 37819253
2-Oxabicyclo[2.1.1]hexanes: Synthesis, Properties, and Validation as Bioisosteres of ortho- and meta-Benzenes.
Levterov VV, Panasiuk Y, Shablykin O, Stashkevych O, Sahun K, Rassokhin A, Sadkova I, Lesyk D, Anisiforova A, Holota Y, Borysko P, Bodenchuk I, Voloshchuk NM, Mykhailiuk PK. Levterov VV, et al. Among authors: shablykin o. Angew Chem Int Ed Engl. 2024 May 6;63(19):e202319831. doi: 10.1002/anie.202319831. Epub 2024 Apr 3. Angew Chem Int Ed Engl. 2024. PMID: 38465464
Spiro[3.3]heptane as a Saturated Benzene Bioisostere.
Prysiazhniuk K, Datsenko OP, Polishchuk O, Shulha S, Shablykin O, Nikandrova Y, Horbatok K, Bodenchuk I, Borysko P, Shepilov D, Pishel I, Kubyshkin V, Mykhailiuk PK. Prysiazhniuk K, et al. Among authors: shablykin o. Angew Chem Int Ed Engl. 2024 Feb 26;63(9):e202316557. doi: 10.1002/anie.202316557. Epub 2024 Jan 22. Angew Chem Int Ed Engl. 2024. PMID: 38251921
14 results