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Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes.
Petrovic N, Walden TB, Shabalina IG, Timmons JA, Cannon B, Nedergaard J. Petrovic N, et al. J Biol Chem. 2010 Mar 5;285(10):7153-64. doi: 10.1074/jbc.M109.053942. Epub 2009 Dec 22. J Biol Chem. 2010. PMID: 20028987 Free PMC article.
Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects.
Shabalina IG, Hoeks J, Kramarova TV, Schrauwen P, Cannon B, Nedergaard J. Shabalina IG, et al. Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):968-80. doi: 10.1016/j.bbabio.2010.02.033. Epub 2010 Mar 19. Biochim Biophys Acta. 2010. PMID: 20227385 Free article.
The Environmental Pollutants Perfluorooctane Sulfonate and Perfluorooctanoic Acid Upregulate Uncoupling Protein 1 (UCP1) in Brown-Fat Mitochondria Through a UCP1-Dependent Reduction in Food Intake.
Shabalina IG, Kramarova TV, Mattsson CL, Petrovic N, Rahman Qazi M, Csikasz RI, Chang SC, Butenhoff J, DePierre JW, Cannon B, Nedergaard J. Shabalina IG, et al. Toxicol Sci. 2015 Aug;146(2):334-43. doi: 10.1093/toxsci/kfv098. Epub 2015 May 21. Toxicol Sci. 2015. PMID: 26001964
69 results