Sgourakis NG - Search Results

1

High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange.

Overall SA, Toor JS, Hao S, Yarmarkovich M, Sara M O'Rourke, Morozov GI, Nguyen S, Japp AS, Gonzalez N, Moschidi D, Betts MR, Maris JM, Smibert P, Sgourakis NG. Overall SA, et al. Among authors: sgourakis ng. Nat Commun. 2020 Apr 20;11(1):1909. doi: 10.1038/s41467-020-15710-1. Nat Commun. 2020. PMID: 32312993 Free PMC article.

2

An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role.

Natarajan K, McShan AC, Jiang J, Kumirov VK, Wang R, Zhao H, Schuck P, Tilahun ME, Boyd LF, Ying J, Bax A, Margulies DH, Sgourakis NG. Natarajan K, et al. Among authors: sgourakis ng. Nat Commun. 2017 May 16;8:15260. doi: 10.1038/ncomms15260. Nat Commun. 2017. PMID: 28508865 Free PMC article.

3

A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations.

Toor JS, Rao AA, McShan AC, Yarmarkovich M, Nerli S, Yamaguchi K, Madejska AA, Nguyen S, Tripathi S, Maris JM, Salama SR, Haussler D, Sgourakis NG. Toor JS, et al. Among authors: sgourakis ng. Front Immunol. 2018 Jan 30;9:99. doi: 10.3389/fimmu.2018.00099. eCollection 2018. Front Immunol. 2018. PMID: 29441070 Free PMC article.

4

Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle.

McShan AC, Natarajan K, Kumirov VK, Flores-Solis D, Jiang J, Badstübner M, Toor JS, Bagshaw CR, Kovrigin EL, Margulies DH, Sgourakis NG. McShan AC, et al. Among authors: sgourakis ng. Nat Chem Biol. 2018 Aug;14(8):811-820. doi: 10.1038/s41589-018-0096-2. Epub 2018 Jul 9. Nat Chem Biol. 2018. PMID: 29988068 Free PMC article.

5

Programmable design of orthogonal protein heterodimers.

Chen Z, Boyken SE, Jia M, Busch F, Flores-Solis D, Bick MJ, Lu P, VanAernum ZL, Sahasrabuddhe A, Langan RA, Bermeo S, Brunette TJ, Mulligan VK, Carter LP, DiMaio F, Sgourakis NG, Wysocki VH, Baker D. Chen Z, et al. Among authors: sgourakis ng. Nature. 2019 Jan;565(7737):106-111. doi: 10.1038/s41586-018-0802-y. Epub 2018 Dec 19. Nature. 2019. PMID: 30568301 Free PMC article.

6

Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection.

McShan AC, Devlin CA, Overall SA, Park J, Toor JS, Moschidi D, Flores-Solis D, Choi H, Tripathi S, Procko E, Sgourakis NG. McShan AC, et al. Among authors: sgourakis ng. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25602-25613. doi: 10.1073/pnas.1915562116. Epub 2019 Dec 3. Proc Natl Acad Sci U S A. 2019. PMID: 31796585 Free PMC article.

7

Computational design of closely related proteins that adopt two well-defined but structurally divergent folds.

Wei KY, Moschidi D, Bick MJ, Nerli S, McShan AC, Carter LP, Huang PS, Fletcher DA, Sgourakis NG, Boyken SE, Baker D. Wei KY, et al. Among authors: sgourakis ng. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7208-7215. doi: 10.1073/pnas.1914808117. Epub 2020 Mar 18. Proc Natl Acad Sci U S A. 2020. PMID: 32188784 Free PMC article.

8

Production of soluble pMHC-I molecules in mammalian cells using the molecular chaperone TAPBPR.

O'Rourke SM, Morozov GI, Roberts JT, Barb AW, Sgourakis NG. O'Rourke SM, et al. Among authors: sgourakis ng. Protein Eng Des Sel. 2019 Dec 31;32(12):525-532. doi: 10.1093/protein/gzaa015. Protein Eng Des Sel. 2019. PMID: 32725167 Free PMC article.

9

Backbone-independent NMR resonance assignments of methyl probes in large proteins.

Nerli S, De Paula VS, McShan AC, Sgourakis NG. Nerli S, et al. Among authors: sgourakis ng. Nat Commun. 2021 Jan 29;12(1):691. doi: 10.1038/s41467-021-20984-0. Nat Commun. 2021. PMID: 33514730 Free PMC article.

10

TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap.

McShan AC, Devlin CA, Morozov GI, Overall SA, Moschidi D, Akella N, Procko E, Sgourakis NG. McShan AC, et al. Among authors: sgourakis ng. Nat Commun. 2021 May 26;12(1):3174. doi: 10.1038/s41467-021-23225-6. Nat Commun. 2021. PMID: 34039964 Free PMC article.

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