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2021 | 2 |
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Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.
Biol Psychiatry. 2022 Jan 1;91(1):102-117. doi: 10.1016/j.biopsych.2021.02.972. Epub 2021 Mar 23.
Biol Psychiatry. 2022.
PMID: 34099189
Free PMC article.
BACKGROUND: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders sugg …
BACKGROUND: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar dis …
Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits.
Martin J, Khramtsova EA, Goleva SB, Blokland GAM, Traglia M, Walters RK, Hübel C, Coleman JRI, Breen G, Børglum AD, Demontis D, Grove J, Werge T, Bralten J, Bulik CM, Lee PH, Mathews CA, Peterson RE, Winham SJ, Wray N, Edenberg HJ, Guo W, Yao Y, Neale BM, Faraone SV, Petryshen TL, Weiss LA, Duncan LE, Goldstein JM, Smoller JW, Stranger BE, Davis LK; Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium.
Martin J, et al.
Biol Psychiatry. 2021 Jun 15;89(12):1127-1137. doi: 10.1016/j.biopsych.2020.12.024. Epub 2021 Jan 9.
Biol Psychiatry. 2021.
PMID: 33648717
Free PMC article.
For each trait, we computed per-SNP z scores from sex-stratified regression coefficients and identified genes with sex-differentiated effects using a gene-based approach. ...We identified 4 genes with significant sex-differentiated effects across 3 traits. Se …
For each trait, we computed per-SNP z scores from sex-stratified regression coefficients and identified genes with sex-differe …
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