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Peroxiredoxins and Beyond; Redox Systems Regulating Lung Physiology and Disease.
Elko EA, Cunniff B, Seward DJ, Chia SB, Aboushousha R, van de Wetering C, van der Velden J, Manuel A, Shukla A, Heintz NH, Anathy V, van der Vliet A, Janssen-Heininger YMW. Elko EA, et al. Among authors: seward dj. Antioxid Redox Signal. 2019 Nov 10;31(14):1070-1091. doi: 10.1089/ars.2019.7752. Epub 2019 Apr 5. Antioxid Redox Signal. 2019. PMID: 30799628 Free PMC article. Review.
Paradoxical roles of dual oxidases in cancer biology.
Little AC, Sulovari A, Danyal K, Heppner DE, Seward DJ, van der Vliet A. Little AC, et al. Among authors: seward dj. Free Radic Biol Med. 2017 Sep;110:117-132. doi: 10.1016/j.freeradbiomed.2017.05.024. Epub 2017 May 31. Free Radic Biol Med. 2017. PMID: 28578013 Free PMC article. Review.
Reducing protein oxidation reverses lung fibrosis.
Anathy V, Lahue KG, Chapman DG, Chia SB, Casey DT, Aboushousha R, van der Velden JLJ, Elko E, Hoffman SM, McMillan DH, Jones JT, Nolin JD, Abdalla S, Schneider R, Seward DJ, Roberson EC, Liptak MD, Cousins ME, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, Ho YS, Hakem R, Brown KK, Matsui R, Bachschmid MM, Gomez JL, Kaminski N, van der Vliet A, Janssen-Heininger YMW. Anathy V, et al. Among authors: seward dj. Nat Med. 2018 Aug;24(8):1128-1135. doi: 10.1038/s41591-018-0090-y. Epub 2018 Jul 9. Nat Med. 2018. PMID: 29988126 Free PMC article.
Dysregulation of the glutaredoxin/S-glutathionylation redox axis in lung diseases.
Chia SB, Elko EA, Aboushousha R, Manuel AM, van de Wetering C, Druso JE, van der Velden J, Seward DJ, Anathy V, Irvin CG, Lam YW, van der Vliet A, Janssen-Heininger YMW. Chia SB, et al. Among authors: seward dj. Am J Physiol Cell Physiol. 2020 Feb 1;318(2):C304-C327. doi: 10.1152/ajpcell.00410.2019. Epub 2019 Nov 6. Am J Physiol Cell Physiol. 2020. PMID: 31693398 Free PMC article.
Glutathionylation chemistry promotes interleukin-1 beta-mediated glycolytic reprogramming and pro-inflammatory signaling in lung epithelial cells.
Aboushousha R, Elko E, Chia SB, Manuel AM, van de Wetering C, van der Velden J, MacPherson M, Erickson C, Reisz JA, D'Alessandro A, Wouters EFM, Reynaert NL, Lam YW, Anathy V, van der Vliet A, Seward DJ, Janssen-Heininger YMW. Aboushousha R, et al. Among authors: seward dj. FASEB J. 2021 May;35(5):e21525. doi: 10.1096/fj.202002687RR. FASEB J. 2021. PMID: 33817836 Free PMC article.
Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema.
Schiffers C, Lundblad LKA, Hristova M, Habibovic A, Dustin CM, Daphtary N, Aliyeva M, Seward DJ, Janssen-Heininger YMW, Wouters EFM, Reynaert NL, van der Vliet A. Schiffers C, et al. Among authors: seward dj. Am J Physiol Lung Cell Mol Physiol. 2021 Jul 1;321(1):L144-L158. doi: 10.1152/ajplung.00021.2021. Epub 2021 May 5. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 33951398 Free PMC article.
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