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Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice.
Nat Commun. 2021 Sep 3;12(1):5213. doi: 10.1038/s41467-021-25453-2.
Nat Commun. 2021.
PMID: 34480023
Free PMC article.
Expression of p16INK4a is a biomarker of chondrocyte aging but does not cause osteoarthritis.
Diekman BO, Sessions GA, Collins JA, Knecht AK, Strum SL, Mitin NK, Carlson CS, Loeser RF, Sharpless NE.
Diekman BO, et al. Among authors: sessions ga.
Aging Cell. 2018 Aug;17(4):e12771. doi: 10.1111/acel.12771. Epub 2018 May 9.
Aging Cell. 2018.
PMID: 29744983
Free PMC article.
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Controlled induction and targeted elimination of p16INK4a-expressing chondrocytes in cartilage explant culture.
Sessions GA, Copp ME, Liu JY, Sinkler MA, D'Costa S, Diekman BO.
Sessions GA, et al.
FASEB J. 2019 Nov;33(11):12364-12373. doi: 10.1096/fj.201900815RR. Epub 2019 Aug 13.
FASEB J. 2019.
PMID: 31408372
Free PMC article.
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Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis.
Copp ME, Chubinskaya S, Bracey DN, Shine J, Sessions G, Loeser RF, Diekman BO.
Copp ME, et al.
Aging Cell. 2022 Sep;21(9):e13698. doi: 10.1111/acel.13698. Epub 2022 Aug 22.
Aging Cell. 2022.
PMID: 35996812
Free PMC article.
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Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence.
Liu JY, Souroullas GP, Diekman BO, Krishnamurthy J, Hall BM, Sorrentino JA, Parker JS, Sessions GA, Gudkov AV, Sharpless NE.
Liu JY, et al. Among authors: sessions ga.
Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2603-2611. doi: 10.1073/pnas.1818313116. Epub 2019 Jan 25.
Proc Natl Acad Sci U S A. 2019.
PMID: 30683717
Free PMC article.
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The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence.
Copp ME, Flanders MC, Gagliardi R, Gilbertie JM, Sessions GA, Chubinskaya S, Loeser RF, Schnabel LV, Diekman BO.
Copp ME, et al. Among authors: sessions ga.
Osteoarthritis Cartilage. 2021 Mar;29(3):402-412. doi: 10.1016/j.joca.2020.11.004. Epub 2020 Nov 20.
Osteoarthritis Cartilage. 2021.
PMID: 33227437
Free PMC article.
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