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Year Number of Results
1945 2
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1957 12
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1960 3
1961 4
1962 3
1963 7
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1969 27
1970 44
1971 19
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1973 11
1974 11
1975 10
1976 10
1977 8
1978 5
1979 16
1980 17
1981 10
1982 9
1983 17
1984 31
1985 26
1986 29
1987 27
1988 41
1989 41
1990 38
1991 51
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1994 95
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1999 137
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2001 166
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2003 251
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11,426 results

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Page 1
Showing results for serine ae
Search for Serize AE instead (2 results)
Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD.
Ghrayeb A, Finney AC, Agranovich B, Peled D, Anand SK, McKinney MP, Sarji M, Yang D, Weissman N, Drucker S, Fernandes SI, Fernández-García J, Mahan K, Abassi Z, Tan L, Lorenzi PL, Traylor J, Zhang J, Abramovich I, Chen YE, Rom O, Mor I, Gottlieb E. Ghrayeb A, et al. Cell Metab. 2024 Jan 2;36(1):116-129.e7. doi: 10.1016/j.cmet.2023.12.013. Cell Metab. 2024. PMID: 38171331
The levels of glycine, a central component of one-carbon metabolism, were lower in mice with hepatic steatosis, consistent with clinical evidence. Stable-isotope tracing demonstrated that increased serine synthesis from glycine via reverse serine hydroxymethyltransf …
The levels of glycine, a central component of one-carbon metabolism, were lower in mice with hepatic steatosis, consistent with clinical evi …
Efficacy of Adjunctive D-Cycloserine to Intermittent Theta-Burst Stimulation for Major Depressive Disorder: A Randomized Clinical Trial.
Cole J, Sohn MN, Harris AD, Bray SL, Patten SB, McGirr A. Cole J, et al. JAMA Psychiatry. 2022 Dec 1;79(12):1153-1161. doi: 10.1001/jamapsychiatry.2022.3255. JAMA Psychiatry. 2022. PMID: 36223114 Free PMC article. Clinical Trial.
IMPORTANCE: The antidepressant effects of transcranial magnetic stimulation protocols for major depressive disorder (MDD) are thought to depend on synaptic plasticity. ...This was reflected in lower CGI-severity ratings and greater CGI-improvement ratings. No serious ad …
IMPORTANCE: The antidepressant effects of transcranial magnetic stimulation protocols for major depressive disorder (MDD) are thought …
Pharmacokinetics and toxicokinetics of d-serine in rats.
Hasegawa H, Masuda N, Natori H, Shinohara Y, Ichida K. Hasegawa H, et al. J Pharm Biomed Anal. 2019 Jan 5;162:264-271. doi: 10.1016/j.jpba.2018.09.026. Epub 2018 Sep 14. J Pharm Biomed Anal. 2019. PMID: 30268994
The oral bioavailability of d-serine was estimated to be 94 27%. To evaluate the dose-response relationship of d-serine-induced kidney injury and the plasma kinetics of d-serine, we injected d-serine into rats ip in doses ranging from 0.6 to 4.8 mmol/k …
The oral bioavailability of d-serine was estimated to be 94 27%. To evaluate the dose-response relationship of d-serine-induce …
Evidence for effect of l-serine, a novel therapy for GRIN2B-related neurodevelopmental disorder.
den Hollander B, Veenvliet ARJ, Rothuizen-Lindenschot M, van Essen P, Peters G, Santos-Gómez A, Olivella M, Altafaj X, Brands MM, Jacobs BAW, van Karnebeek CD. den Hollander B, et al. Mol Genet Metab. 2023 Mar;138(3):107523. doi: 10.1016/j.ymgme.2023.107523. Epub 2023 Jan 21. Mol Genet Metab. 2023. PMID: 36758276 Free article.
Initial reports of GRIN2B-NDD patients LoF variants, treated with l-serine using different regimens, showed varying effects on motor and cognitive performance, communication, behavior and EEG. ...Outcome measures included laboratory tests, quality of life, sleep, ir …
Initial reports of GRIN2B-NDD patients LoF variants, treated with l-serine using different regimens, showed varying effects on …
L-Serine Treatment is Associated with Improvements in Behavior, EEG, and Seizure Frequency in Individuals with GRIN-Related Disorders Due to Null Variants.
Krey I, von Spiczak S, Johannesen KM, Hikel C, Kurlemann G, Muhle H, Beysen D, Dietel T, Møller RS, Lemke JR, Syrbe S. Krey I, et al. Neurotherapeutics. 2022 Jan;19(1):334-341. doi: 10.1007/s13311-021-01173-9. Epub 2022 Jan 7. Neurotherapeutics. 2022. PMID: 34997442 Free PMC article.
A second individual with a GoF missense variant was erroneously treated with L-serine and experienced immediate temporary behavioral deterioration further supporting the supposed functional pathomechanism. ...None of these nine individuals experienced side effects o …
A second individual with a GoF missense variant was erroneously treated with L-serine and experienced immediate temporary behavioral …
Antitubercular therapy-induced psychosis.
Singanamala B, Saini L, Madaan P, Singh P, Vaidya PC, Sahu JK. Singanamala B, et al. Neurology. 2019 Dec 3;93(23):1012-1013. doi: 10.1212/WNL.0000000000008578. Neurology. 2019. PMID: 31792104 No abstract available.
L-Serine Supplementation Blunts Fasting-Induced Weight Regain by Increasing Brown Fat Thermogenesis.
López-Gonzales E, Lehmann L, Ruiz-Ojeda FJ, Hernández-Bautista R, Altun I, Onogi Y, Khalil AE, Liu X, Israel A, Ussar S. López-Gonzales E, et al. Nutrients. 2022 May 4;14(9):1922. doi: 10.3390/nu14091922. Nutrients. 2022. PMID: 35565889 Free PMC article.
Thus, novel interventions maintaining reduced body weight are critically important to prevent metabolic disease. Here we investigate the metabolic effects of dietary L-serine supplementation, known to modulate various organ functions. ...Conversely, L-serine …
Thus, novel interventions maintaining reduced body weight are critically important to prevent metabolic disease. Here we investigate the met …
Targeting Serine in Cancer: Is Two Better Than One?
Buqué A, Galluzzi L, Montrose DC. Buqué A, et al. Trends Cancer. 2021 Aug;7(8):668-670. doi: 10.1016/j.trecan.2021.06.004. Epub 2021 Jul 1. Trends Cancer. 2021. PMID: 34219053 Free PMC article.
Several recent preclinical studies have demonstrated that simultaneously blocking exogenous and endogenous sources of serine in malignant cells mediates superior anticancer effects as compared with limiting either source alone. Here, we critically summarize key deve …
Several recent preclinical studies have demonstrated that simultaneously blocking exogenous and endogenous sources of serine in malig …
Protein Serine/Threonine Phosphatase Type 2C of Leishmania mexicana.
Escalona-Montaño AR, Zuñiga-Fabián M, Cabrera N, Mondragón-Flores R, Gómez-Sandoval JN, Rojas-Bernabé A, González-Canto A, Gutiérrez-Kobeh L, Pérez-Montfort R, Becker I, Aguirre-García MM. Escalona-Montaño AR, et al. Front Cell Infect Microbiol. 2021 Apr 15;11:641356. doi: 10.3389/fcimb.2021.641356. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 33937094 Free PMC article.
Phosphoprotein phosphatases (PPPs), one of three families of protein serine/threonine phosphatases, have great structural diversity and are involved in regulating many cell functions. ...
Phosphoprotein phosphatases (PPPs), one of three families of protein serine/threonine phosphatases, have great structural diversity a …
The Treatment of Primary Orthostatic Hypotension.
Hale GM, Valdes J, Brenner M. Hale GM, et al. Ann Pharmacother. 2017 May;51(5):417-428. doi: 10.1177/1060028016689264. Epub 2017 Jan 16. Ann Pharmacother. 2017. PMID: 28092986 Review.
Medication management of primary OH should be guided by patient-specific factors, such as tolerability, adverse effects, and drug-drug and drug-disease interactions....
Medication management of primary OH should be guided by patient-specific factors, such as tolerability, adverse effects, and d …
11,426 results
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