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β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models.
Goiran T, Duplan E, Chami M, Bourgeois A, El Manaa W, Rouland L, Dunys J, Lauritzen I, You H, Stambolic V, Biféri MG, Barkats M, Pimplikar SW, Sergeant N, Colin M, Morais VA, Pardossi-Piquard R, Checler F, Alves da Costa C. Goiran T, et al. Among authors: sergeant n. Biol Psychiatry. 2018 Mar 1;83(5):416-427. doi: 10.1016/j.biopsych.2017.04.011. Epub 2017 May 3. Biol Psychiatry. 2018. PMID: 28587718 Free article.
Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies.
Vingtdeux V, Hamdane M, Loyens A, Gelé P, Drobeck H, Bégard S, Galas MC, Delacourte A, Beauvillain JC, Buée L, Sergeant N. Vingtdeux V, et al. Among authors: sergeant n. J Biol Chem. 2007 Jun 22;282(25):18197-18205. doi: 10.1074/jbc.M609475200. Epub 2007 Apr 27. J Biol Chem. 2007. PMID: 17468104 Free article.
., Delacourte, A., Beauvillain, J.-C., Buee, L., Marambaud, P., and Sergeant, N. (2007) Neurobiol. Dis. 25, 686-696). Herein, we aimed to determine the cell compartment in which AICD accumulates. ...
., Delacourte, A., Beauvillain, J.-C., Buee, L., Marambaud, P., and Sergeant, N. (2007) Neurobiol. Dis. 25, 686-696). Herein, …
Nuclear tau, a key player in neuronal DNA protection.
Sultan A, Nesslany F, Violet M, Bégard S, Loyens A, Talahari S, Mansuroglu Z, Marzin D, Sergeant N, Humez S, Colin M, Bonnefoy E, Buée L, Galas MC. Sultan A, et al. Among authors: sergeant n. J Biol Chem. 2011 Feb 11;286(6):4566-75. doi: 10.1074/jbc.M110.199976. Epub 2010 Dec 3. J Biol Chem. 2011. PMID: 21131359 Free PMC article.
[Molecular actors in Alzheimer's disease: which diagnostic and therapeutic consequences?].
Buée L, Blum D, Bombois S, Buée-Scherrer V, Caillet-Boudin ML, Colin M, Deramecourt V, Dhaenens CM, Galas MC, Hamdane M, Humez S, Maurage CA, Pasquier F, Sablonnière B, Schraen-Maschke S, Sergeant N. Buée L, et al. Among authors: sergeant n. Therapie. 2010 Sep-Oct;65(5):401-7. doi: 10.2515/therapie/2010054. Epub 2010 Dec 13. Therapie. 2010. PMID: 21144474 French.
Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N. Vingtdeux V, et al. Among authors: sergeant n. Neurobiol Dis. 2005 Nov;20(2):625-37. doi: 10.1016/j.nbd.2005.05.004. Epub 2005 Jun 3. Neurobiol Dis. 2005. PMID: 15936948
Chloroquine and chloroquinoline derivatives as models for the design of modulators of amyloid Peptide precursor metabolism.
Melnyk P, Vingtdeux V, Burlet S, Eddarkaoui S, Grosjean ME, Larchanché PE, Hochart G, Sergheraert C, Estrella C, Barrier M, Poix V, Plancq P, Lannoo C, Hamdane M, Delacourte A, Verwaerde P, Buée L, Sergeant N. Melnyk P, et al. Among authors: sergeant n. ACS Chem Neurosci. 2015 Apr 15;6(4):559-69. doi: 10.1021/cn5003013. Epub 2015 Feb 6. ACS Chem Neurosci. 2015. PMID: 25611616
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors.
Gay M, Evrard C, Descamps F, Carato P, Renault N, Coevoet M, Eddarkaoui S, Baud C, Larchanché PE, Buée L, El Bakali J, Vingtdeux V, Sergeant N, Melnyk P. Gay M, et al. Among authors: sergeant n. Eur J Med Chem. 2018 Nov 5;159:104-125. doi: 10.1016/j.ejmech.2018.08.092. Epub 2018 Sep 22. Eur J Med Chem. 2018. PMID: 30268822
138 results