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Loss of intestinal sympathetic innervation elicits an innate immune driven colitis.
Willemze RA, Welting O, van Hamersveld P, Verseijden C, Nijhuis LE, Hilbers FW, Meijer SL, Heesters BA, Folgering JHA, Darwinkel H, Blancou P, Vervoordeldonk MJ, Seppen J, Heinsbroek SEM, de Jonge WJ. Willemze RA, et al. Among authors: seppen j. Mol Med. 2019 Jan 7;25(1):1. doi: 10.1186/s10020-018-0068-8. Mol Med. 2019. PMID: 30616543 Free PMC article.
Neuronal control of experimental colitis occurs via sympathetic intestinal innervation.
Willemze RA, Welting O, van Hamersveld HP, Meijer SL, Folgering JHA, Darwinkel H, Witherington J, Sridhar A, Vervoordeldonk MJ, Seppen J, de Jonge WJ. Willemze RA, et al. Among authors: seppen j. Neurogastroenterol Motil. 2018 Mar;30(3). doi: 10.1111/nmo.13163. Epub 2017 Jul 26. Neurogastroenterol Motil. 2018. PMID: 28745812
Neuronal innervation of the intestinal crypt.
Ten Hove AS, Seppen J, de Jonge WJ. Ten Hove AS, et al. Among authors: seppen j. Am J Physiol Gastrointest Liver Physiol. 2021 Feb 1;320(2):G193-G205. doi: 10.1152/ajpgi.00239.2020. Epub 2020 Dec 9. Am J Physiol Gastrointest Liver Physiol. 2021. PMID: 33296267 Free article. Review.
Acetylcholine-producing T cells augment innate immune-driven colitis but are redundant in T cell-driven colitis.
Willemze RA, Brinkman DJ, Welting O, van Hamersveld PHP, Verseijden C, Luyer MD, Wildenberg ME, Seppen J, de Jonge WJ. Willemze RA, et al. Among authors: seppen j. Am J Physiol Gastrointest Liver Physiol. 2019 Nov 1;317(5):G557-G568. doi: 10.1152/ajpgi.00067.2019. Epub 2019 Jul 19. Am J Physiol Gastrointest Liver Physiol. 2019. PMID: 31322912 Free article.
Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity.
Dhawan S, De Palma G, Willemze RA, Hilbers FW, Verseijden C, Luyer MD, Nuding S, Wehkamp J, Souwer Y, de Jong EC, Seppen J, van den Wijngaard RM, Wehner S, Verdu E, Bercik P, de Jonge WJ. Dhawan S, et al. Among authors: seppen j. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 1;311(5):G920-G933. doi: 10.1152/ajpgi.00114.2016. Epub 2016 Aug 11. Am J Physiol Gastrointest Liver Physiol. 2016. PMID: 27514477 Free article.
Painful interactions: Microbial compounds and visceral pain.
van Thiel IAM, Botschuijver S, de Jonge WJ, Seppen J. van Thiel IAM, et al. Among authors: seppen j. Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1;1866(1):165534. doi: 10.1016/j.bbadis.2019.165534. Epub 2019 Oct 18. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 31634534 Free article. Review.
Intestinal Fungal Dysbiosis Is Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats.
Botschuijver S, Roeselers G, Levin E, Jonkers DM, Welting O, Heinsbroek SEM, de Weerd HH, Boekhout T, Fornai M, Masclee AA, Schuren FHJ, de Jonge WJ, Seppen J, van den Wijngaard RM. Botschuijver S, et al. Among authors: seppen j. Gastroenterology. 2017 Oct;153(4):1026-1039. doi: 10.1053/j.gastro.2017.06.004. Epub 2017 Jun 15. Gastroenterology. 2017. PMID: 28624575
Exclusive enteral nutrition mediates gut microbial and metabolic changes that are associated with remission in children with Crohn's disease.
Diederen K, Li JV, Donachie GE, de Meij TG, de Waart DR, Hakvoort TBM, Kindermann A, Wagner J, Auyeung V, Te Velde AA, Heinsbroek SEM, Benninga MA, Kinross J, Walker AW, de Jonge WJ, Seppen J. Diederen K, et al. Among authors: seppen j. Sci Rep. 2020 Nov 3;10(1):18879. doi: 10.1038/s41598-020-75306-z. Sci Rep. 2020. PMID: 33144591 Free PMC article.
Reversal of visceral hypersensitivity in rat by Menthacarin® , a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation.
Botschuijver S, Welting O, Levin E, Maria-Ferreira D, Koch E, Montijn RC, Seppen J, Hakvoort TBM, Schuren FHJ, de Jonge WJ, van den Wijngaard RM. Botschuijver S, et al. Among authors: seppen j. Neurogastroenterol Motil. 2018 Jun;30(6):e13299. doi: 10.1111/nmo.13299. Epub 2018 Jan 31. Neurogastroenterol Motil. 2018. PMID: 29383802
72 results