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A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.
Eteläinen TS, Silva MC, Uhari-Väänänen JK, De Lorenzo F, Jäntti MH, Cui H, Chavero-Pieres M, Kilpeläinen T, Mechtler C, Svarcbahs R, Seppälä E, Savinainen JR, Puris E, Fricker G, Gynther M, Julku UH, Huttunen HJ, Haggarty SJ, Myöhänen TT. Eteläinen TS, et al. Among authors: seppala e. Sci Transl Med. 2023 Apr 12;15(691):eabq2915. doi: 10.1126/scitranslmed.abq2915. Epub 2023 Apr 12. Sci Transl Med. 2023. PMID: 37043557
5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein-Protein Interaction-Derived Functions.
Pätsi HT, Kilpeläinen TP, Jumppanen M, Uhari-Väänänen J, Wielendaele PV, De Lorenzo F, Cui H, Auno S, Saharinen J, Seppälä E, Sipari N, Savinainen J, De Meester I, Lambeir AM, Lahtela-Kakkonen M, Myöhänen TT, Wallén EAA. Pätsi HT, et al. Among authors: seppala e. J Med Chem. 2024 Apr 11;67(7):5421-5436. doi: 10.1021/acs.jmedchem.3c01993. Epub 2024 Mar 28. J Med Chem. 2024. PMID: 38546708
New perspectives on respiratory syncytial virus surveillance at the national level: lessons from the COVID-19 pandemic.
Teirlinck AC, Johannesen CK, Broberg EK, Penttinen P, Campbell H, Nair H, Reeves RM, Bøås H, Brytting M, Cai W, Carnahan A, Casalegno JS, Danis K, De Gascun C, Ellis J, Emborg HD, Gijon M, Guiomar R, Hirve SS, Jiřincová H, Nohynek H, Oliva JA, Osei-Yeboah R, Paget J, Pakarna G, Pebody R, Presser L, Rapp M, Reiche J, Rodrigues AP, Seppälä E, Socan M, Szymanski K, Trebbien R, Večeřová J, van der Werf S, Zambon M, Meijer A, Fischer TK. Teirlinck AC, et al. Among authors: seppala e. Eur Respir J. 2023 Apr 3;61(4):2201569. doi: 10.1183/13993003.01569-2022. Print 2023 Apr. Eur Respir J. 2023. PMID: 37012081 Free PMC article.
High vaccine effectiveness against coronavirus disease 2019 (COVID-19) and severe disease among residents and staff of long-term care facilities in Norway, November 2020-June 2021.
Starrfelt J, Danielsen AS, Kacelnik O, Wang Børseth A, Seppälä E, Meijerink H. Starrfelt J, et al. Among authors: seppala e. Antimicrob Steward Healthc Epidemiol. 2022 Jan 17;2(1):e10. doi: 10.1017/ash.2021.246. eCollection 2022. Antimicrob Steward Healthc Epidemiol. 2022. PMID: 36310780 Free PMC article.
Age-specific associations between underlying health conditions and hospitalisation, death and in-hospital death among confirmed COVID-19 cases: a multi-country study based on surveillance data, June to December 2020.
Funk T, Innocenti F, Gomes Dias J, Nerlander L, Melillo T, Gauci C, Melillo JM, Lenz P, Sebestova H, Slezak P, Vlckova I, Berild JD, Mauroy C, Seppälä E, Tønnessen R, Vergison A, Mossong J, Masi S, Huiart L, Cullen G, Murphy N, O'Connor L, O'Donnell J, Mook P, Pebody RG, Bundle N. Funk T, et al. Among authors: seppala e. Euro Surveill. 2022 Sep;27(35):2100883. doi: 10.2807/1560-7917.ES.2022.27.35.2100883. Euro Surveill. 2022. PMID: 36052721 Free PMC article.
Randomised clinical non-inferiority trial of breathing-based meditation and cognitive processing therapy for symptoms of post-traumatic stress disorder in military veterans.
Bayley PJ, Schulz-Heik RJ, Tang JS, Mathersul DC, Avery T, Wong M, Zeitzer JM, Rosen CS, Burn AS, Hernandez B, Lazzeroni LC, Seppälä EM. Bayley PJ, et al. Among authors: seppala em. BMJ Open. 2022 Aug 25;12(8):e056609. doi: 10.1136/bmjopen-2021-056609. BMJ Open. 2022. PMID: 36008059 Free PMC article. Clinical Trial.
Milder disease trajectory among COVID-19 patients hospitalised with the SARS-CoV-2 Omicron variant compared with the Delta variant in Norway.
Stålcrantz J, Kristoffersen AB, Bøås H, Veneti L, Seppälä E, Aasand N, Hungnes O, Kvåle R, Bragstad K, Buanes EA, Whittaker R. Stålcrantz J, et al. Among authors: seppala e. Scand J Public Health. 2022 Aug;50(6):676-682. doi: 10.1177/14034948221108548. Epub 2022 Jul 7. Scand J Public Health. 2022. PMID: 35799474
150 results