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Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.
Vidal RL, Sepulveda D, Troncoso-Escudero P, Garcia-Huerta P, Gonzalez C, Plate L, Jerez C, Canovas J, Rivera CA, Castillo V, Cisternas M, Leal S, Martinez A, Grandjean J, Sonia D, Lashuel HA, Martin AJM, Latapiat V, Matus S, Sardi SP, Wiseman RL, Hetz C. Vidal RL, et al. Among authors: sepulveda d. Mol Ther. 2021 May 5;29(5):1862-1882. doi: 10.1016/j.ymthe.2021.01.033. Epub 2021 Feb 3. Mol Ther. 2021. PMID: 33545358 Free PMC article.
IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson's disease models.
Arcos J, Grunenwald F, Sepulveda D, Jerez C, Urbina V, Huerta T, Troncoso-Escudero P, Tirado D, Perez A, Diaz-Espinoza R, Nova E, Kubitscheck U, Rodriguez-Gatica JE, Hetz C, Toledo J, Ahumada P, Rojas-Rivera D, Martín-Montañez E, Garcia-Fernandez M, Vidal RL. Arcos J, et al. Among authors: sepulveda d. Cell Death Discov. 2023 Dec 2;9(1):438. doi: 10.1038/s41420-023-01734-1. Cell Death Discov. 2023. PMID: 38042807 Free PMC article.
Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis.
Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M. Groenendyk J, et al. Among authors: sepulveda d. Sci Signal. 2014 Jun 10;7(329):ra54. doi: 10.1126/scisignal.2004983. Sci Signal. 2014. PMID: 24917591 Free PMC article.
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α.
Sepulveda D, Rojas-Rivera D, Rodríguez DA, Groenendyk J, Köhler A, Lebeaupin C, Ito S, Urra H, Carreras-Sureda A, Hazari Y, Vasseur-Cognet M, Ali MMU, Chevet E, Campos G, Godoy P, Vaisar T, Bailly-Maitre B, Nagata K, Michalak M, Sierralta J, Hetz C. Sepulveda D, et al. Mol Cell. 2018 Jan 18;69(2):238-252.e7. doi: 10.1016/j.molcel.2017.12.028. Mol Cell. 2018. PMID: 29351844 Free article.
ER stress sensing mechanism: Putting off the brake on UPR transducers.
Rojas-Rivera D, Rodriguez DA, Sepulveda D, Hetz C. Rojas-Rivera D, et al. Among authors: sepulveda d. Oncotarget. 2018 Apr 13;9(28):19461-19462. doi: 10.18632/oncotarget.25114. eCollection 2018 Apr 13. Oncotarget. 2018. PMID: 29731957 Free PMC article. No abstract available.
156 results