Estrogen induces EGR1 to fine-tune its actions on uterine epithelium by controlling PR signaling for successful embryo implantation.
Kim HR, Kim YS, Yoon JA, Yang SC, Park M, Seol DW, Lyu SW, Jun JH, Lim HJ, Lee DR, Song H.
Kim HR, et al.
FASEB J. 2018 Mar;32(3):1184-1195. doi: 10.1096/fj.201700854RR. Epub 2018 Jan 3.
FASEB J. 2018.
PMID: 29092905
Although serum levels of E(2) and P(4) were comparable between Egr1(+/+) and Egr1(-/-) mice on d 4 of pregnancy, aberrantly reduced levels of progesterone receptor in Egr1(-/-) uterine ECs caused enhanced E(2) activity and impaired P(4) response. ...-Kim, H.-R., Kim, Y. S. …
Although serum levels of E(2) and P(4) were comparable between Egr1(+/+) and Egr1(-/-) mice on d 4 of pregnancy, aberrantly reduced l …