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Entrectinib, a TRK/ROS1 inhibitor with anti-CNS tumor activity: differentiation from other inhibitors in its class due to weak interaction with P-glycoprotein.
Fischer H, Ullah M, de la Cruz CC, Hunsaker T, Senn C, Wirz T, Wagner B, Draganov D, Vazvaei F, Donzelli M, Paehler A, Merchant M, Yu L. Fischer H, et al. Among authors: senn c. Neuro Oncol. 2020 Jun 9;22(6):819-829. doi: 10.1093/neuonc/noaa052. Neuro Oncol. 2020. PMID: 32383735 Free PMC article.
Calculation of an Apical Efflux Ratio from P-Glycoprotein (P-gp) In Vitro Transport Experiments Shows an Improved Correlation with In Vivo Cerebrospinal Fluid Measurements in Rats: Impact on P-gp Screening and Compound Optimization.
Fischer H, Senn C, Ullah M, Cantrill C, Schuler F, Yu L. Fischer H, et al. Among authors: senn c. J Pharmacol Exp Ther. 2021 Mar;376(3):322-329. doi: 10.1124/jpet.120.000158. Epub 2020 Dec 7. J Pharmacol Exp Ther. 2021. PMID: 33288523
Preputial diverticulum dilation in a Goettingen minipig.
Denk N, Senn C, Jacobsen B, Schnitzer T. Denk N, et al. Among authors: senn c. Lab Anim. 2018 Feb;52(1):93-97. doi: 10.1177/0023677217735550. Epub 2017 Oct 9. Lab Anim. 2018. PMID: 28992802
109 results