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Iron chelators target both proliferating and quiescent cancer cells.
Fryknäs M, Zhang X, Bremberg U, Senkowski W, Olofsson MH, Brandt P, Persson I, D'Arcy P, Gullbo J, Nygren P, Schughart LK, Linder S, Larsson R. Fryknäs M, et al. Among authors: senkowski w. Sci Rep. 2016 Dec 7;6:38343. doi: 10.1038/srep38343. Sci Rep. 2016. PMID: 27924826 Free PMC article.
The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation.
Blom K, Senkowski W, Jarvius M, Berglund M, Rubin J, Lenhammar L, Parrow V, Andersson C, Loskog A, Fryknäs M, Nygren P, Larsson R. Blom K, et al. Among authors: senkowski w. Immunopharmacol Immunotoxicol. 2017 Aug;39(4):199-210. doi: 10.1080/08923973.2017.1320671. Epub 2017 May 4. Immunopharmacol Immunotoxicol. 2017. PMID: 28472897
Targeting tumor cells based on Phosphodiesterase 3A expression.
Nazir M, Senkowski W, Nyberg F, Blom K, Edqvist PH, Jarvius M, Andersson C, Gustafsson MG, Nygren P, Larsson R, Fryknäs M. Nazir M, et al. Among authors: senkowski w. Exp Cell Res. 2017 Dec 15;361(2):308-315. doi: 10.1016/j.yexcr.2017.10.032. Epub 2017 Oct 26. Exp Cell Res. 2017. PMID: 29107068
Descriptive Proteome Analysis to Investigate Context-Dependent Treatment Responses to OXPHOS Inhibition in Colon Carcinoma Cells Grown as Monolayer and Multicellular Tumor Spheroids.
Steinmetz J, Senkowski W, Lengqvist J, Rubin J, Ossipova E, Herman S, Larsson R, Jakobsson PJ, Fryknäs M, Kultima K. Steinmetz J, et al. Among authors: senkowski w. ACS Omega. 2020 Jul 6;5(28):17242-17254. doi: 10.1021/acsomega.0c01419. eCollection 2020 Jul 21. ACS Omega. 2020. PMID: 32715210 Free PMC article.
14 results