Senior MM - Search Results

1

NMR-based approaches for lead discovery.

Wyss DF, McCoy MA, Senior MM. Wyss DF, et al. Among authors: senior mm. Curr Opin Drug Discov Devel. 2002 Jul;5(4):630-47. Curr Opin Drug Discov Devel. 2002. PMID: 12197321 Review.

2

Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation.

McCoy MA, Gesell JJ, Senior MM, Wyss DF. McCoy MA, et al. Among authors: senior mm. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1645-8. doi: 10.1073/pnas.0334477100. Epub 2003 Jan 27. Proc Natl Acad Sci U S A. 2003. PMID: 12552135 Free PMC article.

3

Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.

Wyss DF, Arasappan A, Senior MM, Wang YS, Beyer BM, Njoroge FG, McCoy MA. Wyss DF, et al. Among authors: senior mm. J Med Chem. 2004 May 6;47(10):2486-98. doi: 10.1021/jm0305117. J Med Chem. 2004. PMID: 15115392

4

Screening of protein kinases by ATP-STD NMR spectroscopy.

McCoy MA, Senior MM, Wyss DF. McCoy MA, et al. Among authors: senior mm. J Am Chem Soc. 2005 Jun 8;127(22):7978-9. doi: 10.1021/ja0425942. J Am Chem Soc. 2005. PMID: 15926798

5

Characterization of autocatalytic conversion of precursor BACE1 by heteronuclear NMR spectroscopy.

Wang YS, Beyer BM, Senior MM, Wyss DF. Wang YS, et al. Among authors: senior mm. Biochemistry. 2005 Dec 20;44(50):16594-601. doi: 10.1021/bi051040o. Biochemistry. 2005. PMID: 16342950

6

Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.

Wang YS, Strickland C, Voigt JH, Kennedy ME, Beyer BM, Senior MM, Smith EM, Nechuta TL, Madison VS, Czarniecki M, McKittrick BA, Stamford AW, Parker EM, Hunter JC, Greenlee WJ, Wyss DF. Wang YS, et al. Among authors: senior mm. J Med Chem. 2010 Feb 11;53(3):942-50. doi: 10.1021/jm901472u. J Med Chem. 2010. PMID: 20043700

7

Solution structure and dynamics of the single-chain hepatitis C virus NS3 protease NS4A cofactor complex.

McCoy MA, Senior MM, Gesell JJ, Ramanathan L, Wyss DF. McCoy MA, et al. Among authors: senior mm. J Mol Biol. 2001 Feb 2;305(5):1099-110. doi: 10.1006/jmbi.2000.4365. J Mol Biol. 2001. PMID: 11162117

8

Ras oncoprotein inhibitors: the discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex.

Taveras AG, Remiszewski SW, Doll RJ, Cesarz D, Huang EC, Kirschmeier P, Pramanik BN, Snow ME, Wang YS, del Rosario JD, Vibulbhan B, Bauer BB, Brown JE, Carr D, Catino J, Evans CA, Girijavallabhan V, Heimark L, James L, Liberles S, Nash C, Perkins L, Senior MM, Tsarbopoulos A, Webber SE, et al. Taveras AG, et al. Among authors: senior mm. Bioorg Med Chem. 1997 Jan;5(1):125-33. doi: 10.1016/s0968-0896(96)00202-7. Bioorg Med Chem. 1997. PMID: 9043664

9

Unambiguous structural characterization of hydantoin reaction products using 2D HMBC NMR spectroscopy.

Senior MM, Chan TM, Li G, Huang Y, Stamford A. Senior MM, et al. Magn Reson Chem. 2007 Mar;45(3):240-4. doi: 10.1002/mrc.1956. Magn Reson Chem. 2007. PMID: 17278178

10

Chemical shift assignments and secondary structure of the Grb2 SH2 domain by heteronuclear NMR spectroscopy.

Wang YS, Frederick AF, Senior MM, Lyons BA, Black S, Kirschmeier P, Perkins LM, Wilson O. Wang YS, et al. Among authors: senior mm. J Biomol NMR. 1996 Mar;7(2):89-98. doi: 10.1007/BF00203819. J Biomol NMR. 1996. PMID: 8616273

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