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Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease.
Vanni I, Pirisinu L, Acevedo-Morantes C, Kamali-Jamil R, Rathod V, Di Bari MA, D'Agostino C, Marcon S, Esposito E, Riccardi G, Hornemann S, Senatore A, Aguzzi A, Agrimi U, Wille H, Nonno R. Vanni I, et al. Among authors: senatore a. Brain. 2020 May 1;143(5):1512-1524. doi: 10.1093/brain/awaa078. Brain. 2020. PMID: 32303068 Free PMC article.
The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models.
Kamali-Jamil R, Vázquez-Fernández E, Tancowny B, Rathod V, Amidian S, Wang X, Tang X, Fang A, Senatore A, Hornemann S, Dudas S, Aguzzi A, Young HS, Wille H. Kamali-Jamil R, et al. Among authors: senatore a. PLoS Pathog. 2021 Jun 1;17(6):e1009628. doi: 10.1371/journal.ppat.1009628. eCollection 2021 Jun. PLoS Pathog. 2021. PMID: 34061899 Free PMC article.
Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication.
Frontzek K, Pfammatter M, Sorce S, Senatore A, Schwarz P, Moos R, Frauenknecht K, Hornemann S, Aguzzi A. Frontzek K, et al. Among authors: senatore a. PLoS One. 2016 Sep 29;11(9):e0163601. doi: 10.1371/journal.pone.0163601. eCollection 2016. PLoS One. 2016. PMID: 27684562 Free PMC article.
Protective anti-prion antibodies in human immunoglobulin repertoires.
Senatore A, Frontzek K, Emmenegger M, Chincisan A, Losa M, Reimann R, Horny G, Guo J, Fels S, Sorce S, Zhu C, George N, Ewert S, Pietzonka T, Hornemann S, Aguzzi A. Senatore A, et al. EMBO Mol Med. 2020 Sep 7;12(9):e12739. doi: 10.15252/emmm.202012739. Epub 2020 Aug 10. EMBO Mol Med. 2020. PMID: 32776637 Free PMC article.
Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity.
Goniotaki D, Lakkaraju AKK, Shrivastava AN, Bakirci P, Sorce S, Senatore A, Marpakwar R, Hornemann S, Gasparini F, Triller A, Aguzzi A. Goniotaki D, et al. Among authors: senatore a. PLoS Pathog. 2017 Nov 27;13(11):e1006733. doi: 10.1371/journal.ppat.1006733. eCollection 2017 Nov. PLoS Pathog. 2017. PMID: 29176838 Free PMC article.
A conformational switch controlling the toxicity of the prion protein.
Frontzek K, Bardelli M, Senatore A, Henzi A, Reimann RR, Bedir S, Marino M, Hussain R, Jurt S, Meisl G, Pedotti M, Mazzola F, Siligardi G, Zerbe O, Losa M, Knowles T, Lakkaraju A, Zhu C, Schwarz P, Hornemann S, Holt MG, Simonelli L, Varani L, Aguzzi A. Frontzek K, et al. Among authors: senatore a. Nat Struct Mol Biol. 2022 Aug;29(8):831-840. doi: 10.1038/s41594-022-00814-7. Epub 2022 Aug 10. Nat Struct Mol Biol. 2022. PMID: 35948768 Free PMC article.
102 results