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Development of a robust, sensitive and selective liquid chromatography-tandem mass spectrometry assay for the quantification of the novel macrocyclic peptide kappa opioid receptor antagonist [D-Trp]CJ-15,208 in plasma and application to an initial pharmacokinetic study.
Khaliq T, Williams TD, Senadheera SN, Aldrich JV. Khaliq T, et al. Among authors: senadheera sn. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Aug 15;1028:11-15. doi: 10.1016/j.jchromb.2016.05.043. Epub 2016 Jun 2. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27318293 Free PMC article.
Tryptophan Substitution in CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Extinguished Cocaine-Conditioned Place Preference.
Scherrer KH, Eans SO, Medina JM, Senadheera SN, Khaliq T, Murray TF, McLaughlin JP, Aldrich JV. Scherrer KH, et al. Among authors: senadheera sn. Pharmaceuticals (Basel). 2023 Aug 29;16(9):1218. doi: 10.3390/ph16091218. Pharmaceuticals (Basel). 2023. PMID: 37765026 Free PMC article.
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