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PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation.
Farabaugh KT, Krokowski D, Guan BJ, Gao Z, Gao XH, Wu J, Jobava R, Ray G, de Jesus TJ, Bianchi MG, Chukwurah E, Bussolati O, Kilberg M, Buchner DA, Sen GC, Cotton C, McDonald C, Longworth M, Ramakrishnan P, Hatzoglou M. Farabaugh KT, et al. Among authors: sen gc. Elife. 2020 Mar 16;9:e52241. doi: 10.7554/eLife.52241. Elife. 2020. PMID: 32175843 Free PMC article.
Molecular basis for PKR activation by PACT or dsRNA.
Li S, Peters GA, Ding K, Zhang X, Qin J, Sen GC. Li S, et al. Among authors: sen gc. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10005-10. doi: 10.1073/pnas.0602317103. Epub 2006 Jun 19. Proc Natl Acad Sci U S A. 2006. PMID: 16785445 Free PMC article.
Biochemical analysis of PKR activation by PACT.
Peters GA, Dickerman B, Sen GC. Peters GA, et al. Among authors: sen gc. Biochemistry. 2009 Aug 11;48(31):7441-7. doi: 10.1021/bi900433y. Biochemistry. 2009. PMID: 19580324 Free PMC article.
251 results