Sem DS - Search Results

1

Discovery of two novel (4-hydroxyphenyl) substituted polycyclic carbocycles as potent and selective estrogen receptor beta agonists.

Wetzel EA, Marks KJ, Gleason AA, Brown-Ford S, Reid TE, Chaudhury S, Lindeman S, Sem DS, Donaldson WA. Wetzel EA, et al. Among authors: sem ds. Bioorg Med Chem Lett. 2022 Oct 1;73:128906. doi: 10.1016/j.bmcl.2022.128906. Epub 2022 Jul 20. Bioorg Med Chem Lett. 2022. PMID: 35870729

2

Probing the human estrogen receptor-α binding requirements for phenolic mono- and di-hydroxyl compounds: a combined synthesis, binding and docking study.

McCullough C, Neumann TS, Gone JR, He Z, Herrild C, Wondergem Nee Lukesh J, Pandey RK, Donaldson WA, Sem DS. McCullough C, et al. Among authors: sem ds. Bioorg Med Chem. 2014 Jan 1;22(1):303-10. doi: 10.1016/j.bmc.2013.11.024. Epub 2013 Nov 21. Bioorg Med Chem. 2014. PMID: 24315190 Free PMC article.

3

Generation of Molecular Complexity from Cyclooctatetraene: Preparation of Aminobicyclo[5.1.0]octitols.

El-Mansy MF, Flister M, Lindeman S, Kalous K, Sem DS, Donaldson WA. El-Mansy MF, et al. Among authors: sem ds. Chemistry. 2015 Jul 20;21(30):10886-95. doi: 10.1002/chem.201501274. Epub 2015 Jun 19. Chemistry. 2015. PMID: 26096989

4

A-C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions.

Hanson AM, Perera KLIS, Kim J, Pandey RK, Sweeney N, Lu X, Imhoff A, Mackinnon AC, Wargolet AJ, Van Hart RM, Frick KM, Donaldson WA, Sem DS. Hanson AM, et al. Among authors: sem ds. J Med Chem. 2018 Jun 14;61(11):4720-4738. doi: 10.1021/acs.jmedchem.7b01601. Epub 2018 Jun 4. J Med Chem. 2018. PMID: 29741891 Free PMC article.

5

Synthesis and evaluation of 4-cycloheptylphenols as selective Estrogen receptor-β agonists (SERBAs).

Sampathi Perera KLI, Hanson AM, Lindeman S, Imhoff A, Lu X, Sem DS, Donaldson WA. Sampathi Perera KLI, et al. Among authors: sem ds. Eur J Med Chem. 2018 Sep 5;157:791-804. doi: 10.1016/j.ejmech.2018.08.006. Epub 2018 Aug 11. Eur J Med Chem. 2018. PMID: 30144697

6

Synthesis and evaluation of 17α-triazolyl and 9α-cyano derivatives of estradiol.

Wetzel EA, Hanson AM, Troutfetter CL, Burkett DJ, Sem DS, Donaldson WA. Wetzel EA, et al. Among authors: sem ds. Bioorg Med Chem. 2020 Oct 1;28(19):115670. doi: 10.1016/j.bmc.2020.115670. Epub 2020 Jul 29. Bioorg Med Chem. 2020. PMID: 32912438 Free PMC article.

7

Long-term oral administration of a novel estrogen receptor beta agonist enhances memory and alleviates drug-induced vasodilation in young ovariectomized mice.

Fleischer AW, Schalk JC, Wetzel EA, Hanson AM, Sem DS, Donaldson WA, Frick KM. Fleischer AW, et al. Among authors: sem ds. Horm Behav. 2021 Apr;130:104948. doi: 10.1016/j.yhbeh.2021.104948. Epub 2021 Mar 8. Horm Behav. 2021. PMID: 33571507 Free PMC article.

8

Homology-modeled ligand-binding domains of zebrafish estrogen receptors alpha, beta1, and beta2: from in silico to in vivo studies of estrogen interactions in Danio rerio as a model system.

Costache AD, Pullela PK, Kasha P, Tomasiewicz H, Sem DS. Costache AD, et al. Among authors: sem ds. Mol Endocrinol. 2005 Dec;19(12):2979-90. doi: 10.1210/me.2004-0435. Epub 2005 Aug 4. Mol Endocrinol. 2005. PMID: 16081519

9

Chemical proteomics-based drug design: target and antitarget fishing with a catechol-rhodanine privileged scaffold for NAD(P)(H) binding proteins.

Ge X, Wakim B, Sem DS. Ge X, et al. Among authors: sem ds. J Med Chem. 2008 Aug 14;51(15):4571-80. doi: 10.1021/jm8002284. Epub 2008 Jul 11. J Med Chem. 2008. PMID: 18616236

10

Chemical proteomics-based analysis of off-target binding profiles for rosiglitazone and pioglitazone: clues for assessing potential for cardiotoxicity.

Hoffmann BR, El-Mansy MF, Sem DS, Greene AS. Hoffmann BR, et al. Among authors: sem ds. J Med Chem. 2012 Oct 11;55(19):8260-71. doi: 10.1021/jm301204r. Epub 2012 Sep 28. J Med Chem. 2012. PMID: 22970990 Free PMC article.

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