Selkoe D - Search Results

1

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.

Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Fanning S, et al. Among authors: selkoe d. Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4. Mol Cell. 2019. PMID: 30527540 Free PMC article.

2

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease.

Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. Sharon R, et al. Neuron. 2003 Feb 20;37(4):583-95. doi: 10.1016/s0896-6273(03)00024-2. Neuron. 2003. PMID: 12597857 Free article.

3

Evidence that alpha-synuclein does not inhibit phospholipase D.

Rappley I, Gitler AD, Selvy PE, LaVoie MJ, Levy BD, Brown HA, Lindquist S, Selkoe DJ. Rappley I, et al. Among authors: selkoe dj. Biochemistry. 2009 Feb 10;48(5):1077-83. doi: 10.1021/bi801871h. Biochemistry. 2009. PMID: 19146388 Free PMC article.

4

In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.

Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. Dettmer U, et al. Among authors: selkoe d. J Biol Chem. 2013 Mar 1;288(9):6371-85. doi: 10.1074/jbc.M112.403311. Epub 2013 Jan 14. J Biol Chem. 2013. PMID: 23319586 Free PMC article.

We recently reported that alphaSyn can instead exist in cells as a helically folded tetramer that resists aggregation and binds lipid vesicles more avidly than unfolded recombinant monomers (Bartels, T., Choi, J. G., and Selkoe, D. J. (2011) Nature 477, 107-110). Ho …

We recently reported that alphaSyn can instead exist in cells as a helically folded tetramer that resists aggregation and binds lipid vesicl …

5

Defining the native state of α-synuclein.

Selkoe D, Dettmer U, Luth E, Kim N, Newman A, Bartels T. Selkoe D, et al. Neurodegener Dis. 2014;13(2-3):114-7. doi: 10.1159/000355516. Epub 2013 Oct 30. Neurodegener Dis. 2014. PMID: 24192542 Review.

6

A new method for quantitative immunoblotting of endogenous α-synuclein.

Newman AJ, Selkoe D, Dettmer U. Newman AJ, et al. Among authors: selkoe d. PLoS One. 2013 Nov 20;8(11):e81314. doi: 10.1371/journal.pone.0081314. eCollection 2013. PLoS One. 2013. PMID: 24278419 Free PMC article.

7

Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.

Luth ES, Bartels T, Dettmer U, Kim NC, Selkoe DJ. Luth ES, et al. Biochemistry. 2015 Jan 20;54(2):279-92. doi: 10.1021/bi501188a. Epub 2014 Dec 23. Biochemistry. 2015. PMID: 25490121 Free PMC article.

8

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.

Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Dettmer U, et al. Among authors: selkoe d. Nat Commun. 2015 Jun 16;6:7314. doi: 10.1038/ncomms8314. Nat Commun. 2015. PMID: 26076669 Free PMC article.

9

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.

Dettmer U, Newman AJ, von Saucken VE, Bartels T, Selkoe D. Dettmer U, et al. Among authors: selkoe d. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9596-601. doi: 10.1073/pnas.1505953112. Epub 2015 Jul 7. Proc Natl Acad Sci U S A. 2015. PMID: 26153422 Free PMC article.

10

Corrigendum: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.

Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Dettmer U, et al. Among authors: selkoe d. Nat Commun. 2015 Jul 30;6:8008. doi: 10.1038/ncomms9008. Nat Commun. 2015. PMID: 26224447 Free PMC article. No abstract available.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

512 results

Search Page