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201 results

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Page 1
Uptake, efficacy, and systemic distribution of naked, inhaled short interfering RNA (siRNA) and locked nucleic acid (LNA) antisense.
Moschos SA, Frick M, Taylor B, Turnpenny P, Graves H, Spink KG, Brady K, Lamb D, Collins D, Rockel TD, Weber M, Lazari O, Perez-Tosar L, Fancy SA, Lapthorn C, Green MX, Evans S, Selby M, Jones G, Jones L, Kearney S, Mechiche H, Gikunju D, Subramanian R, Uhlmann E, Jurk M, Vollmer J, Ciaramella G, Yeadon M. Moschos SA, et al. Among authors: selby m. Mol Ther. 2011 Dec;19(12):2163-8. doi: 10.1038/mt.2011.206. Epub 2011 Oct 4. Mol Ther. 2011. PMID: 21971426 Free PMC article.
Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma.
Millan DS, Ballard SA, Chunn S, Dybowski JA, Fulton CK, Glossop PA, Guillabert E, Hewson CA, Jones RM, Lamb DJ, Napier CM, Payne-Cook TA, Renery ER, Selby MD, Tutt MF, Yeadon M. Millan DS, et al. Among authors: selby md. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5826-30. doi: 10.1016/j.bmcl.2011.07.106. Epub 2011 Aug 11. Bioorg Med Chem Lett. 2011. PMID: 21880489
Inhaled adenosine A(2A) receptor agonists for the treatment of chronic obstructive pulmonary disease.
Mantell SJ, Stephenson PT, Monaghan SM, Maw GN, Trevethick MA, Yeadon M, Keir RF, Walker DK, Jones RM, Selby MD, Batchelor DV, Rozze S, Chavaroche H, Hobson TJ, Dodd PG, Lemaitre A, Wright KN, Stuart EF. Mantell SJ, et al. Among authors: selby md. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1284-7. doi: 10.1016/j.bmcl.2008.01.033. Epub 2008 Jan 12. Bioorg Med Chem Lett. 2008. PMID: 18243699
Pyrazole NNRTIs 3: optimisation of physicochemical properties.
Mowbray CE, Corbau R, Hawes M, Jones LH, Mills JE, Perros M, Selby MD, Stupple PA, Webster R, Wood A. Mowbray CE, et al. Among authors: selby md. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5603-6. doi: 10.1016/j.bmcl.2009.08.043. Epub 2009 Aug 14. Bioorg Med Chem Lett. 2009. PMID: 19717303
Click-enabled heterotrifunctional template for sequential bioconjugations.
Beal DM, Albrow VE, Burslem G, Hitchen L, Fernandes C, Lapthorn C, Roberts LR, Selby MD, Jones LH. Beal DM, et al. Among authors: selby md. Org Biomol Chem. 2012 Jan 21;10(3):548-54. doi: 10.1039/c1ob06398g. Epub 2011 Nov 21. Org Biomol Chem. 2012. PMID: 22101938
SAR of a series of inhaled A(2A) agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data.
Mantell SJ, Stephenson PT, Monaghan SM, Maw GN, Trevethick MA, Yeadon M, Walker DK, Selby MD, Batchelor DV, Rozze S, Chavaroche H, Lemaitre A, Wright KN, Whitlock L, Stuart EF, Wright PA, Macintyre F. Mantell SJ, et al. Among authors: selby md. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4471-5. doi: 10.1016/j.bmcl.2009.05.027. Epub 2009 May 12. Bioorg Med Chem Lett. 2009. PMID: 19501510
Inhalation by design: dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD.
Jones LH, Baldock H, Bunnage ME, Burrows J, Clarke N, Coghlan M, Entwistle D, Fairman D, Feeder N, Fulton C, Hilton L, James K, Jones RM, Kenyon AS, Marshall S, Newman SD, Osborne R, Patel S, Selby MD, Stuart EF, Trevethick MA, Wright KN, Price DA. Jones LH, et al. Among authors: selby md. Bioorg Med Chem Lett. 2011 May 1;21(9):2759-63. doi: 10.1016/j.bmcl.2010.10.132. Epub 2010 Oct 31. Bioorg Med Chem Lett. 2011. PMID: 21075627
Molecular hybridization yields triazole bronchodilators for the treatment of COPD.
Jones LH, Burrows J, Feeder N, Glossop P, James K, Jones RM, Kenyon AS, Patel S, Roberts DF, Selby MD, Strang RS, Stuart EF, Trevethick MA, Watson J, Wright KN, Clarke N. Jones LH, et al. Among authors: selby md. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5121-6. doi: 10.1016/j.bmcl.2015.10.008. Epub 2015 Oct 8. Bioorg Med Chem Lett. 2015. PMID: 26471092
Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate.
Mowbray CE, Burt C, Corbau R, Gayton S, Hawes M, Perros M, Tran I, Price DA, Quinton FJ, Selby MD, Stupple PA, Webster R, Wood A. Mowbray CE, et al. Among authors: selby md. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5857-60. doi: 10.1016/j.bmcl.2009.08.080. Epub 2009 Aug 27. Bioorg Med Chem Lett. 2009. PMID: 19748778
201 results