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Melatonin is a potential drug for the prevention of bone loss during space flight.
Ikegame M, Hattori A, Tabata MJ, Kitamura KI, Tabuchi Y, Furusawa Y, Maruyama Y, Yamamoto T, Sekiguchi T, Matsuoka R, Hanmoto T, Ikari T, Endo M, Omori K, Nakano M, Yashima S, Ejiri S, Taya T, Nakashima H, Shimizu N, Nakamura M, Kondo T, Hayakawa K, Takasaki I, Kaminishi A, Akatsuka R, Sasayama Y, Nishiuchi T, Nara M, Iseki H, Chowdhury VS, Wada S, Ijiri K, Takeuchi T, Suzuki T, Ando H, Matsuda K, Somei M, Mishima H, Mikuni-Takagaki Y, Funahashi H, Takahashi A, Watanabe Y, Maeda M, Uchida H, Hayashi A, Kambegawa A, Seki A, Yano S, Shimazu T, Suzuki H, Hirayama J, Suzuki N. Ikegame M, et al. Among authors: seki a. J Pineal Res. 2019 Oct;67(3):e12594. doi: 10.1111/jpi.12594. Epub 2019 Jul 19. J Pineal Res. 2019. PMID: 31286565 Free PMC article.
Oral administration of melatonin contained in drinking water increased bone strength in naturally aged mice.
Igarashi-Migitaka J, Seki A, Ikegame M, Honda M, Sekiguchi T, Mishima H, Shimizu N, Matsubara H, Srivastav AK, Hirayama J, Maruyama Y, Kamijo-Ikemori A, Hirata K, Hattori A, Suzuki N. Igarashi-Migitaka J, et al. Among authors: seki a. Acta Histochem. 2020 Sep;122(6):151596. doi: 10.1016/j.acthis.2020.151596. Epub 2020 Jul 18. Acta Histochem. 2020. PMID: 32778234
582 results