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Transcription of the NKG2D ligand MICA is suppressed by the IRE1/XBP1 pathway of the unfolded protein response through the regulation of E2F1.
Obiedat A, Seidel E, Mahameed M, Berhani O, Tsukerman P, Voutetakis K, Chatziioannou A, McMahon M, Avril T, Chevet E, Mandelboim O, Tirosh B. Obiedat A, et al. Among authors: seidel e. FASEB J. 2019 Mar;33(3):3481-3495. doi: 10.1096/fj.201801350RR. Epub 2018 Nov 19. FASEB J. 2019. PMID: 30452881
Because of the importance of E2F1 and MICA in cancer progression and recognition, these observations could be exploited for cancer therapy by manipulating the UPR in tumor cells.-Obiedat, A., Seidel, E., Mahameed, M., Berhani, O., Tsukerman, P., Voutetakis, K., Chat …
Because of the importance of E2F1 and MICA in cancer progression and recognition, these observations could be exploited for cancer therapy b …
Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR.
Stanietsky N, Rovis TL, Glasner A, Seidel E, Tsukerman P, Yamin R, Enk J, Jonjic S, Mandelboim O. Stanietsky N, et al. Among authors: seidel e. Eur J Immunol. 2013 Aug;43(8):2138-50. doi: 10.1002/eji.201243072. Epub 2013 Jul 4. Eur J Immunol. 2013. PMID: 23677581 Free PMC article.
Cytokine secretion and NK cell activity in human ADAM17 deficiency.
Tsukerman P, Eisenstein EM, Chavkin M, Schmiedel D, Wong E, Werner M, Yaacov B, Averbuch D, Molho-Pessach V, Stepensky P, Kaynan N, Bar-On Y, Seidel E, Yamin R, Sagi I, Elpeleg O, Mandelboim O. Tsukerman P, et al. Among authors: seidel e. Oncotarget. 2015 Dec 29;6(42):44151-60. doi: 10.18632/oncotarget.6629. Oncotarget. 2015. PMID: 26683521 Free PMC article.
213 results