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NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.
Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, Boileau C, Brissette L, Chrétien M, Prat A, Seidah NG. Benjannet S, et al. Among authors: seidah ng. J Biol Chem. 2004 Nov 19;279(47):48865-75. doi: 10.1074/jbc.M409699200. Epub 2004 Sep 9. J Biol Chem. 2004. PMID: 15358785 Free article.
Plasma PCSK9 levels correlate with cholesterol in men but not in women.
Mayne J, Raymond A, Chaplin A, Cousins M, Kaefer N, Gyamera-Acheampong C, Seidah NG, Mbikay M, Chrétien M, Ooi TC. Mayne J, et al. Among authors: seidah ng. Biochem Biophys Res Commun. 2007 Sep 21;361(2):451-6. doi: 10.1016/j.bbrc.2007.07.029. Epub 2007 Jul 18. Biochem Biophys Res Commun. 2007. PMID: 17645871
PCSK9 as a therapeutic target of dyslipidemia.
Seidah NG. Seidah NG. Expert Opin Ther Targets. 2009 Jan;13(1):19-28. doi: 10.1517/14728220802600715. Expert Opin Ther Targets. 2009. PMID: 19063703 Review.
A new method for measurement of total plasma PCSK9: clinical applications.
Dubuc G, Tremblay M, Paré G, Jacques H, Hamelin J, Benjannet S, Boulet L, Genest J, Bernier L, Seidah NG, Davignon J. Dubuc G, et al. Among authors: seidah ng. J Lipid Res. 2010 Jan;51(1):140-9. doi: 10.1194/jlr.M900273-JLR200. J Lipid Res. 2010. PMID: 19571328 Free PMC article.
Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route.
Poirier S, Mayer G, Poupon V, McPherson PS, Desjardins R, Ly K, Asselin MC, Day R, Duclos FJ, Witmer M, Parker R, Prat A, Seidah NG. Poirier S, et al. Among authors: seidah ng. J Biol Chem. 2009 Oct 16;284(42):28856-64. doi: 10.1074/jbc.M109.037085. Epub 2009 Jul 27. J Biol Chem. 2009. PMID: 19635789 Free PMC article.
672 results