Segil N - Search Results

1

STAT3 promotes a youthful epigenetic state in articular chondrocytes.

Sarkar A, Liu NQ, Magallanes J, Tassey J, Lee S, Shkhyan R, Lee Y, Lu J, Ouyang Y, Tang H, Bian F, Tao L, Segil N, Ernst J, Lyons K, Horvath S, Evseenko D. Sarkar A, et al. Among authors: segil n. Aging Cell. 2023 Feb;22(2):e13773. doi: 10.1111/acel.13773. Epub 2023 Jan 13. Aging Cell. 2023. PMID: 36638270 Free PMC article.

2

CDK2 regulates aminoglycoside-induced hair cell death through modulating c-Jun activity: Inhibiting CDK2 to preserve hearing.

Tao L, Segil N. Tao L, et al. Among authors: segil n. Front Mol Neurosci. 2022 Oct 13;15:1013383. doi: 10.3389/fnmol.2022.1013383. eCollection 2022. Front Mol Neurosci. 2022. PMID: 36311033 Free PMC article.

3

SoxC transcription factors shape the epigenetic landscape to establish competence for sensory differentiation in the mammalian organ of Corti.

Wang X, Llamas J, Trecek T, Shi T, Tao L, Makmura W, Crump JG, Segil N, Gnedeva K. Wang X, et al. Among authors: segil n. Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2301301120. doi: 10.1073/pnas.2301301120. Epub 2023 Aug 16. Proc Natl Acad Sci U S A. 2023. PMID: 37585469 Free PMC article.

4

DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration.

Nguyen JD, Llamas J, Shi T, Crump JG, Groves AK, Segil N. Nguyen JD, et al. Among authors: segil n. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2300839120. doi: 10.1073/pnas.2300839120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549271 Free PMC article.

5

Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes.

Shi T, Beaulieu MO, Saunders LM, Fabian P, Trapnell C, Segil N, Crump JG, Raible DW. Shi T, et al. Among authors: segil n. Elife. 2023 Jan 4;12:e82978. doi: 10.7554/eLife.82978. Elife. 2023. PMID: 36598134 Free PMC article.

6

Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals.

Iyer AA, Hosamani I, Nguyen JD, Cai T, Singh S, McGovern MM, Beyer L, Zhang H, Jen HI, Yousaf R, Birol O, Sun JJ, Ray RS, Raphael Y, Segil N, Groves AK. Iyer AA, et al. Among authors: segil n. Elife. 2022 Nov 29;11:e79712. doi: 10.7554/eLife.79712. Elife. 2022. PMID: 36445327 Free PMC article.

7

GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor.

Jen HI, Singh S, Tao L, Maunsell HR, Segil N, Groves AK. Jen HI, et al. Among authors: segil n. Sci Rep. 2022 May 12;12(1):7793. doi: 10.1038/s41598-022-11931-0. Sci Rep. 2022. PMID: 35551236 Free PMC article.

8

Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration.

Tao L, Yu HV, Llamas J, Trecek T, Wang X, Stojanova Z, Groves AK, Segil N. Tao L, et al. Among authors: segil n. Dev Cell. 2021 Sep 13;56(17):2471-2485.e5. doi: 10.1016/j.devcel.2021.07.003. Epub 2021 Jul 30. Dev Cell. 2021. PMID: 34331868 Free PMC article.

9

POU4F3 pioneer activity enables ATOH1 to drive diverse mechanoreceptor differentiation through a feed-forward epigenetic mechanism.

Yu HV, Tao L, Llamas J, Wang X, Nguyen JD, Trecek T, Segil N. Yu HV, et al. Among authors: segil n. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2105137118. doi: 10.1073/pnas.2105137118. Proc Natl Acad Sci U S A. 2021. PMID: 34266958 Free PMC article.

10

Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues.

Kastan N, Gnedeva K, Alisch T, Petelski AA, Huggins DJ, Chiaravalli J, Aharanov A, Shakked A, Tzahor E, Nagiel A, Segil N, Hudspeth AJ. Kastan N, et al. Among authors: segil n. Nat Commun. 2021 May 25;12(1):3100. doi: 10.1038/s41467-021-23395-3. Nat Commun. 2021. PMID: 34035288 Free PMC article.

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