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Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists.
Prat M, Buil MA, Fernández MD, Tort L, Monleón JM, Casals G, Ferrer M, Castro J, Gavaldà A, Miralpeix M, Ramos I, Vilella D, Huerta JM, Espinosa S, Hernández B, Segarra V, Córdoba M. Prat M, et al. Among authors: segarra v. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1736-1741. doi: 10.1016/j.bmcl.2015.02.065. Epub 2015 Mar 5. Bioorg Med Chem Lett. 2015. PMID: 25800115
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).
Prat M, Fernández D, Buil MA, Crespo MI, Casals G, Ferrer M, Tort L, Castro J, Monleón JM, Gavaldà A, Miralpeix M, Ramos I, Doménech T, Vilella D, Antón F, Huerta JM, Espinosa S, López M, Sentellas S, González M, Albertí J, Segarra V, Cárdenas A, Beleta J, Ryder H. Prat M, et al. Among authors: segarra v. J Med Chem. 2009 Aug 27;52(16):5076-92. doi: 10.1021/jm900132z. J Med Chem. 2009. PMID: 19653626
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.
Prat M, Buil MA, Fernández MD, Castro J, Monleón JM, Tort L, Casals G, Ferrer M, Huerta JM, Espinosa S, López M, Segarra V, Gavaldà A, Miralpeix M, Ramos I, Vilella D, González M, Córdoba M, Cárdenas A, Antón F, Beleta J, Ryder H. Prat M, et al. Among authors: segarra v. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3457-61. doi: 10.1016/j.bmcl.2011.03.096. Epub 2011 Apr 3. Bioorg Med Chem Lett. 2011. PMID: 21524581
Application of a phenotypic drug discovery strategy to identify biological and chemical starting points for inhibition of TSLP production in lung epithelial cells.
Orellana A, García-González V, López R, Pascual-Guiral S, Lozoya E, Díaz J, Casals D, Barrena A, Paris S, Andrés M, Segarra V, Vilella D, Malhotra R, Eastwood P, Planagumà A, Miralpeix M, Nueda A. Orellana A, et al. Among authors: segarra v. PLoS One. 2018 Jan 10;13(1):e0189247. doi: 10.1371/journal.pone.0189247. eCollection 2018. PLoS One. 2018. PMID: 29320511 Free PMC article.
Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships.
Gràcia J, Buil MA, Castro J, Eichhorn P, Ferrer M, Gavaldà A, Hernández B, Segarra V, Lehner MD, Moreno I, Pagès L, Roberts RS, Serrat J, Sevilla S, Taltavull J, Andrés M, Cabedo J, Vilella D, Calama E, Carcasona C, Miralpeix M. Gràcia J, et al. Among authors: segarra v. J Med Chem. 2016 Dec 8;59(23):10479-10497. doi: 10.1021/acs.jmedchem.6b00829. Epub 2016 Nov 17. J Med Chem. 2016. PMID: 27933955
92 results