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Page 1
The NIH Somatic Cell Genome Editing program.
Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB Jr, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J; SCGE Consortium. Saha K, et al. Among authors: segal dj. Nature. 2021 Apr;592(7853):195-204. doi: 10.1038/s41586-021-03191-1. Epub 2021 Apr 7. Nature. 2021. PMID: 33828315 Free PMC article. Review.
Highly active zinc-finger nucleases by extended modular assembly.
Bhakta MS, Henry IM, Ousterout DG, Das KT, Lockwood SH, Meckler JF, Wallen MC, Zykovich A, Yu Y, Leo H, Xu L, Gersbach CA, Segal DJ. Bhakta MS, et al. Among authors: segal dj. Genome Res. 2013 Mar;23(3):530-8. doi: 10.1101/gr.143693.112. Epub 2012 Dec 5. Genome Res. 2013. PMID: 23222846 Free PMC article.
Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation.
Seo JW, Ingham ES, Mahakian L, Tumbale S, Wu B, Aghevlian S, Shams S, Baikoghli M, Jain P, Ding X, Goeden N, Dobreva T, Flytzanis NC, Chavez M, Singhal K, Leib R, James ML, Segal DJ, Cheng RH, Silva EA, Gradinaru V, Ferrara KW. Seo JW, et al. Among authors: segal dj. Nat Commun. 2020 Apr 30;11(1):2102. doi: 10.1038/s41467-020-15818-4. Nat Commun. 2020. PMID: 32355221 Free PMC article.
Live-Animal Epigenome Editing: Convergence of Novel Techniques.
Gomez JA, Beitnere U, Segal DJ. Gomez JA, et al. Among authors: segal dj. Trends Genet. 2019 Jul;35(7):527-541. doi: 10.1016/j.tig.2019.04.007. Epub 2019 May 22. Trends Genet. 2019. PMID: 31128888 Free PMC article. Review.
Artificial escape from XCI by DNA methylation editing of the CDKL5 gene.
Halmai JANM, Deng P, Gonzalez CE, Coggins NB, Cameron D, Carter JL, Buchanan FKB, Waldo JJ, Lock SR, Anderson JD, O'Geen H, Segal DJ, Nolta J, Fink KD. Halmai JANM, et al. Among authors: segal dj. Nucleic Acids Res. 2020 Mar 18;48(5):2372-2387. doi: 10.1093/nar/gkz1214. Nucleic Acids Res. 2020. PMID: 31925439 Free PMC article.
An in vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-clinical Animal Models.
Deng P, Halmai JANM, Beitnere U, Cameron D, Martinez ML, Lee CC, Waldo JJ, Thongphanh K, Adhikari A, Copping N, Petkova SP, Lee RD, Lock S, Palomares M, O'Geen H, Carter J, Gonzalez CE, Buchanan FKB, Anderson JD, Fierro FA, Nolta JA, Tarantal AF, Silverman JL, Segal DJ, Fink KD. Deng P, et al. Among authors: segal dj. Front Mol Neurosci. 2022 Jan 27;14:789913. doi: 10.3389/fnmol.2021.789913. eCollection 2021. Front Mol Neurosci. 2022. PMID: 35153670 Free PMC article.
Genome engineering at the dawn of the golden age.
Segal DJ, Meckler JF. Segal DJ, et al. Annu Rev Genomics Hum Genet. 2013;14:135-58. doi: 10.1146/annurev-genom-091212-153435. Epub 2013 May 20. Annu Rev Genomics Hum Genet. 2013. PMID: 23701416 Review.
119 results