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Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.
Bwayi MN, Garcia-Maldonado E, Chai SC, Xie B, Chodankar S, Huber AD, Wu J, Annu K, Wright WC, Lee HM, Seetharaman J, Wang J, Buchman CD, Peng J, Chen T. Bwayi MN, et al. Among authors: seetharaman j. Nucleic Acids Res. 2022 Apr 8;50(6):3254-3275. doi: 10.1093/nar/gkac133. Nucleic Acids Res. 2022. PMID: 35212371 Free PMC article.
Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.
Wang J, Buchman CD, Seetharaman J, Miller DJ, Huber AD, Wu J, Chai SC, Garcia-Maldonado E, Wright WC, Chenge J, Chen T. Wang J, et al. Among authors: seetharaman j. J Am Chem Soc. 2021 Nov 10;143(44):18467-18480. doi: 10.1021/jacs.1c07066. Epub 2021 Oct 14. J Am Chem Soc. 2021. PMID: 34648292 Free PMC article.
Design of activated serine-containing catalytic triads with atomic-level accuracy.
Rajagopalan S, Wang C, Yu K, Kuzin AP, Richter F, Lew S, Miklos AE, Matthews ML, Seetharaman J, Su M, Hunt JF, Cravatt BF, Baker D. Rajagopalan S, et al. Among authors: seetharaman j. Nat Chem Biol. 2014 May;10(5):386-91. doi: 10.1038/nchembio.1498. Epub 2014 Apr 6. Nat Chem Biol. 2014. PMID: 24705591 Free PMC article.
Structural basis of BAK activation in mitochondrial apoptosis initiation.
Singh G, Guibao CD, Seetharaman J, Aggarwal A, Grace CR, McNamara DE, Vaithiyalingam S, Waddell MB, Moldoveanu T. Singh G, et al. Among authors: seetharaman j. Nat Commun. 2022 Jan 11;13(1):250. doi: 10.1038/s41467-021-27851-y. Nat Commun. 2022. PMID: 35017502 Free PMC article.
Computational design of catalytic dyads and oxyanion holes for ester hydrolysis.
Richter F, Blomberg R, Khare SD, Kiss G, Kuzin AP, Smith AJ, Gallaher J, Pianowski Z, Helgeson RC, Grjasnow A, Xiao R, Seetharaman J, Su M, Vorobiev S, Lew S, Forouhar F, Kornhaber GJ, Hunt JF, Montelione GT, Tong L, Houk KN, Hilvert D, Baker D. Richter F, et al. Among authors: seetharaman j. J Am Chem Soc. 2012 Oct 3;134(39):16197-206. doi: 10.1021/ja3037367. Epub 2012 Sep 21. J Am Chem Soc. 2012. PMID: 22871159 Free PMC article.
Expression system for structural and functional studies of human glycosylation enzymes.
Moremen KW, Ramiah A, Stuart M, Steel J, Meng L, Forouhar F, Moniz HA, Gahlay G, Gao Z, Chapla D, Wang S, Yang JY, Prabhakar PK, Johnson R, Rosa MD, Geisler C, Nairn AV, Seetharaman J, Wu SC, Tong L, Gilbert HJ, LaBaer J, Jarvis DL. Moremen KW, et al. Among authors: seetharaman j. Nat Chem Biol. 2018 Feb;14(2):156-162. doi: 10.1038/nchembio.2539. Epub 2017 Dec 18. Nat Chem Biol. 2018. PMID: 29251719 Free PMC article.
Water Networks Repopulate Protein-Ligand Interfaces with Temperature.
Stachowski TR, Vanarotti M, Seetharaman J, Lopez K, Fischer M. Stachowski TR, et al. Among authors: seetharaman j. Angew Chem Int Ed Engl. 2022 Aug 1;61(31):e202112919. doi: 10.1002/anie.202112919. Epub 2022 Jun 21. Angew Chem Int Ed Engl. 2022. PMID: 35648650 Free PMC article.
87 results