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A conserved protonation-dependent switch controls drug binding in the Abl kinase.
Shan Y, Seeliger MA, Eastwood MP, Frank F, Xu H, Jensen MØ, Dror RO, Kuriyan J, Shaw DE. Shan Y, et al. Among authors: seeliger ma. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):139-44. doi: 10.1073/pnas.0811223106. Epub 2008 Dec 24. Proc Natl Acad Sci U S A. 2009. PMID: 19109437 Free PMC article.
An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression.
Albanese SK, Parton DL, Işık M, Rodríguez-Laureano L, Hanson SM, Behr JM, Gradia S, Jeans C, Levinson NM, Seeliger MA, Chodera JD. Albanese SK, et al. Among authors: seeliger ma. Biochemistry. 2018 Aug 7;57(31):4675-4689. doi: 10.1021/acs.biochem.7b01081. Epub 2018 Jul 26. Biochemistry. 2018. PMID: 30004690 Free PMC article.
KA1 Domains: Unity in Mechanistic Diversity.
Paung Y, Seeliger MA. Paung Y, et al. Among authors: seeliger ma. Structure. 2018 Aug 7;26(8):1045-1047. doi: 10.1016/j.str.2018.07.002. Structure. 2018. PMID: 30089246 Free article.
What Makes a Kinase Promiscuous for Inhibitors?
Hanson SM, Georghiou G, Thakur MK, Miller WT, Rest JS, Chodera JD, Seeliger MA. Hanson SM, et al. Among authors: seeliger ma. Cell Chem Biol. 2019 Mar 21;26(3):390-399.e5. doi: 10.1016/j.chembiol.2018.11.005. Epub 2019 Jan 3. Cell Chem Biol. 2019. PMID: 30612951 Free PMC article.
Resistance to kinase inhibition through shortened target engagement.
Rangwala AM, Berger BT, Robers MB, Knapp S, Seeliger MA. Rangwala AM, et al. Among authors: seeliger ma. Mol Cell Oncol. 2022 Jan 22;9(1):2029999. doi: 10.1080/23723556.2022.2029999. eCollection 2022. Mol Cell Oncol. 2022. PMID: 35252553 Free PMC article.
76 results