Seeliger MA - Search Results

1

What Makes a Kinase Promiscuous for Inhibitors?

Hanson SM, Georghiou G, Thakur MK, Miller WT, Rest JS, Chodera JD, Seeliger MA. Hanson SM, et al. Among authors: seeliger ma. Cell Chem Biol. 2019 Mar 21;26(3):390-399.e5. doi: 10.1016/j.chembiol.2018.11.005. Epub 2019 Jan 3. Cell Chem Biol. 2019. PMID: 30612951 Free PMC article.

2

Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles.

Georghiou G, Kleiner RE, Pulkoski-Gross M, Liu DR, Seeliger MA. Georghiou G, et al. Among authors: seeliger ma. Nat Chem Biol. 2012 Feb 19;8(4):366-74. doi: 10.1038/nchembio.792. Nat Chem Biol. 2012. PMID: 22344177 Free PMC article.

3

Metazoan-like signaling in a unicellular receptor tyrosine kinase.

Schultheiss KP, Craddock BP, Tong M, Seeliger M, Miller WT. Schultheiss KP, et al. BMC Biochem. 2013 Feb 12;14:4. doi: 10.1186/1471-2091-14-4. BMC Biochem. 2013. PMID: 23398683 Free PMC article.

4

Kinase inhibitors: an allosteric add-on.

Foda ZH, Seeliger MA. Foda ZH, et al. Among authors: seeliger ma. Nat Chem Biol. 2014 Oct;10(10):796-7. doi: 10.1038/nchembio.1630. Epub 2014 Sep 7. Nat Chem Biol. 2014. PMID: 25195010 No abstract available.

5

Targeting conformational plasticity of protein kinases.

Tong M, Seeliger MA. Tong M, et al. Among authors: seeliger ma. ACS Chem Biol. 2015 Jan 16;10(1):190-200. doi: 10.1021/cb500870a. Epub 2014 Dec 19. ACS Chem Biol. 2015. PMID: 25486330 Review.

6

A dynamically coupled allosteric network underlies binding cooperativity in Src kinase.

Foda ZH, Shan Y, Kim ET, Shaw DE, Seeliger MA. Foda ZH, et al. Among authors: seeliger ma. Nat Commun. 2015 Jan 20;6:5939. doi: 10.1038/ncomms6939. Nat Commun. 2015. PMID: 25600932 Free PMC article.

7

Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity.

Kwarcinski FE, Brandvold KR, Phadke S, Beleh OM, Johnson TK, Meagher JL, Seeliger MA, Stuckey JA, Soellner MB. Kwarcinski FE, et al. Among authors: seeliger ma. ACS Chem Biol. 2016 May 20;11(5):1296-304. doi: 10.1021/acschembio.5b01018. Epub 2016 Mar 1. ACS Chem Biol. 2016. PMID: 26895387 Free PMC article.

8

Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.

Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ. Feldman HC, et al. Among authors: seeliger ma. ACS Chem Biol. 2016 Aug 19;11(8):2195-205. doi: 10.1021/acschembio.5b00940. Epub 2016 Jun 9. ACS Chem Biol. 2016. PMID: 27227314 Free PMC article.

9

Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles.

Aleem S, Georghiou G, Kleiner RE, Guja K, Craddock BP, Lyczek A, Chan AI, Garcia-Diaz M, Miller WT, Liu DR, Seeliger MA. Aleem S, et al. Among authors: seeliger ma. Cell Chem Biol. 2016 Sep 22;23(9):1103-1112. doi: 10.1016/j.chembiol.2016.07.017. Epub 2016 Sep 1. Cell Chem Biol. 2016. PMID: 27593110 Free PMC article.

10

Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites.

Tong M, Pelton JG, Gill ML, Zhang W, Picart F, Seeliger MA. Tong M, et al. Among authors: seeliger ma. Nat Commun. 2017 Dec 18;8(1):2160. doi: 10.1038/s41467-017-02240-6. Nat Commun. 2017. PMID: 29255153 Free PMC article.

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