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Computational and Experimental Druggability Assessment of Human DNA Glycosylases.
Michel M, Visnes T, Homan EJ, Seashore-Ludlow B, Hedenström M, Wiita E, Vallin K, Paulin CBJ, Zhang J, Wallner O, Scobie M, Schmidt A, Jenmalm-Jensen A, Warpman Berglund U, Helleday T. Michel M, et al. ACS Omega. 2019 Jul 5;4(7):11642-11656. doi: 10.1021/acsomega.9b00162. eCollection 2019 Jul 31. ACS Omega. 2019. PMID: 31460271 Free PMC article.
Validation and development of MTH1 inhibitors for treatment of cancer.
Warpman Berglund U, Sanjiv K, Gad H, Kalderén C, Koolmeister T, Pham T, Gokturk C, Jafari R, Maddalo G, Seashore-Ludlow B, Chernobrovkin A, Manoilov A, Pateras IS, Rasti A, Jemth AS, Almlöf I, Loseva O, Visnes T, Einarsdottir BO, Gaugaz FZ, Saleh A, Platzack B, Wallner OA, Vallin KS, Henriksson M, Wakchaure P, Borhade S, Herr P, Kallberg Y, Baranczewski P, Homan EJ, Wiita E, Nagpal V, Meijer T, Schipper N, Rudd SG, Bräutigam L, Lindqvist A, Filppula A, Lee TC, Artursson P, Nilsson JA, Gorgoulis VG, Lehtiö J, Zubarev RA, Scobie M, Helleday T. Warpman Berglund U, et al. Ann Oncol. 2016 Dec;27(12):2275-2283. doi: 10.1093/annonc/mdw429. Epub 2016 Nov 8. Ann Oncol. 2016. PMID: 27827301 Free article.
MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia.
Sanjiv K, Calderón-Montaño JM, Pham TM, Erkers T, Tsuber V, Almlöf I, Höglund A, Heshmati Y, Seashore-Ludlow B, Nagesh Danda A, Gad H, Wiita E, Göktürk C, Rasti A, Friedrich S, Centio A, Estruch M, Våtsveen TK, Struyf N, Visnes T, Scobie M, Koolmeister T, Henriksson M, Wallner O, Sandvall T, Lehmann S, Theilgaard-Mönch K, Garnett MJ, Östling P, Walfridsson J, Helleday T, Warpman Berglund U. Sanjiv K, et al. Cancer Res. 2021 Nov 15;81(22):5733-5744. doi: 10.1158/0008-5472.CAN-21-0061. Epub 2021 Sep 30. Cancer Res. 2021. PMID: 34593524 Free PMC article.
In Situ Target Engagement Studies in Adherent Cells.
Axelsson H, Almqvist H, Otrocka M, Vallin M, Lundqvist S, Hansson P, Karlsson U, Lundbäck T, Seashore-Ludlow B. Axelsson H, et al. ACS Chem Biol. 2018 Apr 20;13(4):942-950. doi: 10.1021/acschembio.7b01079. Epub 2018 Feb 21. ACS Chem Biol. 2018. PMID: 29433316
Early Perspective.
Seashore-Ludlow B, Lundbäck T. Seashore-Ludlow B, et al. J Biomol Screen. 2016 Dec;21(10):1019-1033. doi: 10.1177/1087057116659256. Epub 2016 Jul 20. J Biomol Screen. 2016. PMID: 27401582 Review.
Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine.
Howard TP, Oberlick EM, Rees MG, Arnoff TE, Pham MT, Brenan L, DoCarmo M, Hong AL, Kugener G, Chou HC, Drosos Y, Mathias KM, Ramos P, Seashore-Ludlow B, Giacomelli AO, Wang X, Freeman BB 3rd, Blankenship K, Hoffmann L, Tiv HL, Gokhale PC, Johannessen CM, Stewart EA, Schreiber SL, Hahn WC, Roberts CWM. Howard TP, et al. Clin Cancer Res. 2020 Sep 15;26(18):4995-5006. doi: 10.1158/1078-0432.CCR-19-2717. Epub 2020 Jul 6. Clin Cancer Res. 2020. PMID: 32631955 Free PMC article.
49 results