Sears R - Search Results

1

Protein phosphatase 2A activation as a therapeutic strategy for managing MYC-driven cancers.

Farrington CC, Yuan E, Mazhar S, Izadmehr S, Hurst L, Allen-Petersen BL, Janghorban M, Chung E, Wolczanski G, Galsky M, Sears R, Sangodkar J, Narla G. Farrington CC, et al. Among authors: sears r. J Biol Chem. 2020 Jan 17;295(3):757-770. doi: 10.1074/jbc.RA119.011443. Epub 2019 Dec 10. J Biol Chem. 2020. PMID: 31822503 Free PMC article.

2

Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation.

Arnold HK, Sears RC. Arnold HK, et al. Mol Cell Biol. 2006 Apr;26(7):2832-44. doi: 10.1128/MCB.26.7.2832-2844.2006. Mol Cell Biol. 2006. PMID: 16537924 Free PMC article.

3

A conserved pathway that controls c-Myc protein stability through opposing phosphorylation events occurs in yeast.

Escamilla-Powers JR, Sears RC. Escamilla-Powers JR, et al. Among authors: sears rc. J Biol Chem. 2007 Feb 23;282(8):5432-42. doi: 10.1074/jbc.M611437200. Epub 2006 Dec 27. J Biol Chem. 2007. PMID: 17192266 Free PMC article.

4

Inhibition of c-Myc activity by ribosomal protein L11.

Dai MS, Arnold H, Sun XX, Sears R, Lu H. Dai MS, et al. Among authors: sears r. EMBO J. 2007 Jul 25;26(14):3332-45. doi: 10.1038/sj.emboj.7601776. Epub 2007 Jun 28. EMBO J. 2007. PMID: 17599065 Free PMC article.

5

A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins.

Arnold HK, Sears RC. Arnold HK, et al. Cancer Metastasis Rev. 2008 Jun;27(2):147-58. doi: 10.1007/s10555-008-9128-9. Cancer Metastasis Rev. 2008. PMID: 18246411 Free PMC article. Review.

6

The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc.

Arnold HK, Zhang X, Daniel CJ, Tibbitts D, Escamilla-Powers J, Farrell A, Tokarz S, Morgan C, Sears RC. Arnold HK, et al. EMBO J. 2009 Mar 4;28(5):500-12. doi: 10.1038/emboj.2008.279. Epub 2009 Jan 8. EMBO J. 2009. PMID: 19131971 Free PMC article.

7

The tumor suppressor protein HBP1 is a novel c-myc-binding protein that negatively regulates c-myc transcriptional activity.

Escamilla-Powers JR, Daniel CJ, Farrell A, Taylor K, Zhang X, Byers S, Sears R. Escamilla-Powers JR, et al. Among authors: sears r. J Biol Chem. 2010 Feb 12;285(7):4847-58. doi: 10.1074/jbc.M109.074856. Epub 2009 Dec 11. J Biol Chem. 2010. PMID: 20008325 Free PMC article.

8

Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression.

Zhang X, Farrell AS, Daniel CJ, Arnold H, Scanlan C, Laraway BJ, Janghorban M, Lum L, Chen D, Troxell M, Sears R. Zhang X, et al. Among authors: sears r. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2790-5. doi: 10.1073/pnas.1100764108. Epub 2011 Aug 1. Proc Natl Acad Sci U S A. 2012. PMID: 21808024 Free PMC article.

9

Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis.

Farrell AS, Pelz C, Wang X, Daniel CJ, Wang Z, Su Y, Janghorban M, Zhang X, Morgan C, Impey S, Sears RC. Farrell AS, et al. Mol Cell Biol. 2013 Aug;33(15):2930-49. doi: 10.1128/MCB.01455-12. Epub 2013 May 28. Mol Cell Biol. 2013. PMID: 23716601 Free PMC article.

10

MYC degradation.

Farrell AS, Sears RC. Farrell AS, et al. Cold Spring Harb Perspect Med. 2014 Mar 1;4(3):a014365. doi: 10.1101/cshperspect.a014365. Cold Spring Harb Perspect Med. 2014. PMID: 24591536 Free PMC article. Review.

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