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Cancer cell survival depends on collagen uptake into tumor-associated stroma.
Hsu KS, Dunleavey JM, Szot C, Yang L, Hilton MB, Morris K, Seaman S, Feng Y, Lutz EM, Koogle R, Tomassoni-Ardori F, Saha S, Zhang XM, Zudaire E, Bajgain P, Rose J, Zhu Z, Dimitrov DS, Cuttitta F, Emenaker NJ, Tessarollo L, St Croix B. Hsu KS, et al. Among authors: seaman s. Nat Commun. 2022 Nov 18;13(1):7078. doi: 10.1038/s41467-022-34643-5. Nat Commun. 2022. PMID: 36400786 Free PMC article.
TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI).
Nanda A, Carson-Walter EB, Seaman S, Barber TD, Stampfl J, Singh S, Vogelstein B, Kinzler KW, St Croix B. Nanda A, et al. Among authors: seaman s. Cancer Res. 2004 Feb 1;64(3):817-20. doi: 10.1158/0008-5472.can-03-2408. Cancer Res. 2004. PMID: 14871805
Host-derived tumor endothelial marker 8 promotes the growth of melanoma.
Cullen M, Seaman S, Chaudhary A, Yang MY, Hilton MB, Logsdon D, Haines DC, Tessarollo L, St Croix B. Cullen M, et al. Among authors: seaman s. Cancer Res. 2009 Aug 1;69(15):6021-6. doi: 10.1158/0008-5472.CAN-09-1086. Epub 2009 Jul 21. Cancer Res. 2009. PMID: 19622764 Free PMC article.
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B. Cullen M, et al. Among authors: seaman s. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64. doi: 10.1073/pnas.1017192108. Epub 2011 Mar 18. Proc Natl Acad Sci U S A. 2011. PMID: 21421844 Free PMC article.
GPR124 functions as a WNT7-specific coactivator of canonical β-catenin signaling.
Posokhova E, Shukla A, Seaman S, Volate S, Hilton MB, Wu B, Morris H, Swing DA, Zhou M, Zudaire E, Rubin JS, St Croix B. Posokhova E, et al. Among authors: seaman s. Cell Rep. 2015 Jan 13;10(2):123-30. doi: 10.1016/j.celrep.2014.12.020. Epub 2014 Dec 31. Cell Rep. 2015. PMID: 25558062 Free PMC article.
262 results