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High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma.
Johnston MJ, Nikolic A, Ninkovic N, Guilhamon P, Cavalli FMG, Seaman S, Zemp FJ, Lee J, Abdelkareem A, Ellestad K, Murison A, Kushida MM, Coutinho FJ, Ma Y, Mungall AJ, Moore R, Marra MA, Taylor MD, Dirks PB, Pugh TJ, Morrissy S, St Croix B, Mahoney DJ, Lupien M, Gallo M. Johnston MJ, et al. Among authors: seaman s. Genome Res. 2019 Aug;29(8):1211-1222. doi: 10.1101/gr.246520.118. Epub 2019 Jun 27. Genome Res. 2019. PMID: 31249064 Free PMC article.
The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models.
Kendsersky NM, Lindsay J, Kolb EA, Smith MA, Teicher BA, Erickson SW, Earley EJ, Mosse YP, Martinez D, Pogoriler J, Krytska K, Patel K, Groff D, Tsang M, Ghilu S, Wang Y, Seaman S, Feng Y, Croix BS, Gorlick R, Kurmasheva R, Houghton PJ, Maris JM. Kendsersky NM, et al. Among authors: seaman s. Clin Cancer Res. 2021 May 15;27(10):2938-2946. doi: 10.1158/1078-0432.CCR-20-4221. Epub 2021 Feb 22. Clin Cancer Res. 2021. PMID: 33619171 Free PMC article.
Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability.
Feng Y, Lee J, Yang L, Hilton MB, Morris K, Seaman S, Edupuganti VVSR, Hsu KS, Dower C, Yu G, So D, Bajgain P, Zhu Z, Dimitrov DS, Patel NL, Robinson CM, Difilippantonio S, Dyba M, Corbel A, Basuli F, Swenson RE, Kalen JD, Suthe SR, Hussain M, Italia JS, Souders CA, Gao L, Schnermann MJ, St Croix B. Feng Y, et al. Among authors: seaman s. Cell Rep. 2023 Dec 26;42(12):113503. doi: 10.1016/j.celrep.2023.113503. Epub 2023 Nov 28. Cell Rep. 2023. PMID: 38019654 Free PMC article.
Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release.
Szot C, Saha S, Zhang XM, Zhu Z, Hilton MB, Morris K, Seaman S, Dunleavey JM, Hsu KS, Yu GJ, Morris H, Swing DA, Haines DC, Wang Y, Hwang J, Feng Y, Welsch D, DeCrescenzo G, Chaudhary A, Zudaire E, Dimitrov DS, St Croix B. Szot C, et al. Among authors: seaman s. J Clin Invest. 2018 Jul 2;128(7):2927-2943. doi: 10.1172/JCI120481. Epub 2018 Jun 4. J Clin Invest. 2018. PMID: 29863500 Free PMC article.
TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI).
Nanda A, Carson-Walter EB, Seaman S, Barber TD, Stampfl J, Singh S, Vogelstein B, Kinzler KW, St Croix B. Nanda A, et al. Among authors: seaman s. Cancer Res. 2004 Feb 1;64(3):817-20. doi: 10.1158/0008-5472.can-03-2408. Cancer Res. 2004. PMID: 14871805
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B. Cullen M, et al. Among authors: seaman s. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64. doi: 10.1073/pnas.1017192108. Epub 2011 Mar 18. Proc Natl Acad Sci U S A. 2011. PMID: 21421844 Free PMC article.
263 results