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Page 1
Anti-metastatic immunotherapy based on mucosal administration of flagellin and immunomodulatory P10.
de Melo FM, Braga CJ, Pereira FV, Maricato JT, Origassa CS, Souza MF, Melo AC, Silva P, Tomaz SL, Gimenes KP, Scutti JA, Juliano MA, Zamboni DS, Câmara NO, Travassos LR, Ferreira LC, Rodrigues EG. de Melo FM, et al. Among authors: scutti ja. Immunol Cell Biol. 2015 Jan;93(1):86-98. doi: 10.1038/icb.2014.74. Epub 2014 Sep 16. Immunol Cell Biol. 2015. PMID: 25223833
TLR4-mediated immunomodulatory properties of the bacterial metalloprotease arazyme in preclinical tumor models.
Pereira FV, Melo AC, de Melo FM, Mourão-Sá D, Silva P, Berzaghi R, Herbozo CC, Coelho-Dos-Reis J, Scutti JA, Origassa CS, Pereira RM, Juliano L, Juliano MA, Carmona AK, Câmara NO, Tsuji M, Travassos LR, Rodrigues EG. Pereira FV, et al. Among authors: scutti ja. Oncoimmunology. 2016 May 5;5(7):e1178420. doi: 10.1080/2162402X.2016.1178420. eCollection 2016 Jul. Oncoimmunology. 2016. PMID: 27622031 Free PMC article.
A natural bacterial-derived product, the metalloprotease arazyme, inhibits metastatic murine melanoma by inducing MMP-8 cross-reactive antibodies.
Pereira FV, Ferreira-Guimarães CA, Paschoalin T, Scutti JA, Melo FM, Silva LS, Melo AC, Silva P, Tiago M, Matsuo AL, Juliano L, Juliano MA, Carmona AK, Travassos LR, Rodrigues EG. Pereira FV, et al. Among authors: scutti ja. PLoS One. 2014 Apr 30;9(4):e96141. doi: 10.1371/journal.pone.0096141. eCollection 2014. PLoS One. 2014. PMID: 24788523 Free PMC article.
Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo.
Figueiredo CR, Matsuo AL, Pereira FV, Rabaça AN, Farias CF, Girola N, Massaoka MH, Azevedo RA, Scutti JA, Arruda DC, Silva LP, Rodrigues EG, Lago JH, Travassos LR, Silva RM. Figueiredo CR, et al. Among authors: scutti ja. Pharmacogn Mag. 2014 Apr;10(Suppl 2):S363-76. doi: 10.4103/0973-1296.133284. Pharmacogn Mag. 2014. PMID: 24991116 Free PMC article.
Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo.
Massaoka MH, Matsuo AL, Figueiredo CR, Farias CF, Girola N, Arruda DC, Scutti JA, Romoff P, Favero OA, Ferreira MJ, Lago JH, Travassos LR. Massaoka MH, et al. Among authors: scutti ja. PLoS One. 2012;7(6):e38698. doi: 10.1371/journal.pone.0038698. Epub 2012 Jun 6. PLoS One. 2012. PMID: 22701695 Free PMC article.
α-Pinene isolated from Schinus terebinthifolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model.
Matsuo AL, Figueiredo CR, Arruda DC, Pereira FV, Scutti JA, Massaoka MH, Travassos LR, Sartorelli P, Lago JH. Matsuo AL, et al. Among authors: scutti ja. Biochem Biophys Res Commun. 2011 Jul 29;411(2):449-54. doi: 10.1016/j.bbrc.2011.06.176. Epub 2011 Jul 2. Biochem Biophys Res Commun. 2011. PMID: 21756878 Free article.
Role of SOCS-1 Gene on Melanoma Cell Growth and Tumor Development.
Scutti JA, Matsuo AL, Pereira FV, Massaoka MH, Figueiredo CR, Moreira DF, Belizário JE, Travassos LR. Scutti JA, et al. Transl Oncol. 2011 Apr 1;4(2):101-9. doi: 10.1593/tlo.10250. Transl Oncol. 2011. PMID: 21461173 Free PMC article.