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Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors.
Kosti P, Opzoomer JW, Larios-Martinez KI, Henley-Smith R, Scudamore CL, Okesola M, Taher MYM, Davies DM, Muliaditan T, Larcombe-Young D, Woodman N, Gillett CE, Thavaraj S, Maher J, Arnold JN. Kosti P, et al. Among authors: scudamore cl. Cell Rep Med. 2021 Apr 9;2(4):100227. doi: 10.1016/j.xcrm.2021.100227. eCollection 2021 Apr 20. Cell Rep Med. 2021. PMID: 33948568 Free PMC article.
Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity.
Alliouachene S, Bilanges B, Chicanne G, Anderson KE, Pearce W, Ali K, Valet C, Posor Y, Low PC, Chaussade C, Scudamore CL, Salamon RS, Backer JM, Stephens L, Hawkins PT, Payrastre B, Vanhaesebroeck B. Alliouachene S, et al. Among authors: scudamore cl. Cell Rep. 2015 Dec 1;13(9):1881-94. doi: 10.1016/j.celrep.2015.10.052. Epub 2015 Nov 19. Cell Rep. 2015. PMID: 26655903 Free PMC article.
A guide to post-mortem examination procedure in mouse models.
Rodrigues A, Beresford L, Scudamore CL, Yon M. Rodrigues A, et al. Among authors: scudamore cl. Lab Anim. 2022 Oct;56(5):466-470. doi: 10.1177/00236772221080827. Epub 2022 Mar 31. Lab Anim. 2022. PMID: 35360986 Free article.
Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread.
Wong PP, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford MR, Scudamore CL, Cereser B, Crnogorac-Jurcevic T, McDonald S, Elia G, Hagemann T, Kocher HM, Hodivala-Dilke KM. Wong PP, et al. Among authors: scudamore cl. Cancer Cell. 2015 Jan 12;27(1):123-37. doi: 10.1016/j.ccell.2014.10.015. Cancer Cell. 2015. PMID: 25584895 Free article.
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.
Bilanges B, Alliouachene S, Pearce W, Morelli D, Szabadkai G, Chung YL, Chicanne G, Valet C, Hill JM, Voshol PJ, Collinson L, Peddie C, Ali K, Ghazaly E, Rajeeve V, Trichas G, Srinivas S, Chaussade C, Salamon RS, Backer JM, Scudamore CL, Whitehead MA, Keaney EP, Murphy LO, Semple RK, Payrastre B, Tooze SA, Vanhaesebroeck B. Bilanges B, et al. Among authors: scudamore cl. Nat Commun. 2017 Nov 27;8(1):1804. doi: 10.1038/s41467-017-01969-4. Nat Commun. 2017. PMID: 29180704 Free PMC article.
Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.
Ali K, Soond DR, Pineiro R, Hagemann T, Pearce W, Lim EL, Bouabe H, Scudamore CL, Hancox T, Maecker H, Friedman L, Turner M, Okkenhaug K, Vanhaesebroeck B. Ali K, et al. Among authors: scudamore cl. Nature. 2014 Jun 19;510(7505):407-411. doi: 10.1038/nature13444. Epub 2014 Jun 11. Nature. 2014. PMID: 24919154 Free PMC article.
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