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Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation.
Mirchandani AS, Jenkins SJ, Bain CC, Sanchez-Garcia MA, Lawson H, Coelho P, Murphy F, Griffith DM, Zhang A, Morrison T, Ly T, Arienti S, Sadiku P, Watts ER, Dickinson RS, Reyes L, Cooper G, Clark S, Lewis D, Kelly V, Spanos C, Musgrave KM, Delaney L, Harper I, Scott J, Parkinson NJ, Rostron AJ, Baillie JK, Clohisey S, Pridans C, Campana L, Lewis PS, Simpson AJ, Dockrell DH, Schwarze J, Hirani N, Ratcliffe PJ, Pugh CW, Kranc K, Forbes SJ, Whyte MKB, Walmsley SR. Mirchandani AS, et al. Among authors: scott j. Nat Immunol. 2022 Jun;23(6):927-939. doi: 10.1038/s41590-022-01216-z. Epub 2022 May 27. Nat Immunol. 2022. PMID: 35624205 Free PMC article.
Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by β2-agonists, corticosteroids, and critical illness.
Scott J, Harris GJ, Pinder EM, Macfarlane JG, Hellyer TP, Rostron AJ, Conway Morris A, Thickett DR, Perkins GD, McAuley DF, Widdrington JD, Wiscombe S, Baudouin SV, Roy AI, Linnett VC, Wright SE, Ruchaud-Sparagano MH, Simpson AJ. Scott J, et al. J Allergy Clin Immunol. 2016 Feb;137(2):535-44. doi: 10.1016/j.jaci.2015.07.036. Epub 2015 Sep 18. J Allergy Clin Immunol. 2016. PMID: 26388312 Free article.
The heterogeneity of systemic inflammation in bronchiectasis.
Saleh AD, Chalmers JD, De Soyza A, Fardon TC, Koustas SO, Scott J, Simpson AJ, Brown JS, Hurst JR. Saleh AD, et al. Among authors: scott j. Respir Med. 2017 Jun;127:33-39. doi: 10.1016/j.rmed.2017.04.009. Epub 2017 Apr 17. Respir Med. 2017. PMID: 28502416 Free article.
Mitochondrial DNA depletion induces innate immune dysfunction rescued by IFN-γ.
Widdrington JD, Gomez-Duran A, Steyn JS, Pyle A, Ruchaud-Sparagano MH, Scott J, Baudouin SV, Rostron AJ, Simpson J, Chinnery PF. Widdrington JD, et al. Among authors: scott j. J Allergy Clin Immunol. 2017 Nov;140(5):1461-1464.e8. doi: 10.1016/j.jaci.2017.04.048. Epub 2017 Jun 17. J Allergy Clin Immunol. 2017. PMID: 28629747 Free PMC article. No abstract available.
Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients.
Powell J, Garnett JP, Mather MW, Cooles FAH, Nelson A, Verdon B, Scott J, Jiwa K, Ruchaud-Sparagano MH, Cummings SP, Perry JD, Wright SE, Wilson JA, Pearson J, Ward C, Simpson AJ. Powell J, et al. Among authors: scott j. Am J Respir Crit Care Med. 2018 Aug 1;198(3):340-349. doi: 10.1164/rccm.201709-1819OC. Am J Respir Crit Care Med. 2018. PMID: 29425465
Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis.
Pinder EM, Rostron AJ, Hellyer TP, Ruchaud-Sparagano MH, Scott J, Macfarlane JG, Wiscombe S, Widdrington JD, Roy AI, Linnett VC, Baudouin SV, Wright SE, Chadwick T, Fouweather T, Juss JK, Chilvers ER, Bowett SA, Parker J, McAuley DF, Conway Morris A, Simpson AJ. Pinder EM, et al. Among authors: scott j. Thorax. 2018 Oct;73(10):918-925. doi: 10.1136/thoraxjnl-2017-211323. Epub 2018 Jul 31. Thorax. 2018. PMID: 30064991 Free PMC article. Clinical Trial.
Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses.
Widdrington JD, Gomez-Duran A, Pyle A, Ruchaud-Sparagano MH, Scott J, Baudouin SV, Rostron AJ, Lovat PE, Chinnery PF, Simpson AJ. Widdrington JD, et al. Among authors: scott j. Front Immunol. 2018 Sep 27;9:2217. doi: 10.3389/fimmu.2018.02217. eCollection 2018. Front Immunol. 2018. PMID: 30319656 Free PMC article.
C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodeling.
Wood AJ, Vassallo AM, Ruchaud-Sparagano MH, Scott J, Zinnato C, Gonzalez-Tejedo C, Kishore K, D'Santos CS, Simpson AJ, Menon DK, Summers C, Chilvers ER, Okkenhaug K, Morris AC. Wood AJ, et al. Among authors: scott j. JCI Insight. 2020 Aug 6;5(15):e137029. doi: 10.1172/jci.insight.137029. JCI Insight. 2020. PMID: 32634128 Free PMC article.
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