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Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent.
Mondal A, Saha P, Bose D, Chatterjee S, Seth RK, Xiao S, Porter DE, Brooks BW, Scott GI, Nagarkatti M, Nagarkatti P, Chatterjee S. Mondal A, et al. Among authors: scott gi. Toxicology. 2021 Sep;461:152901. doi: 10.1016/j.tox.2021.152901. Epub 2021 Aug 17. Toxicology. 2021. PMID: 34416350 Free PMC article.
A closed vitrification system enables a murine ovarian follicle bank for high-throughput ovotoxicity screening, which identifies endocrine disrupting activity of microcystins.
Wang Y, Xu J, Stanley JE, Xu M, Brooks BW, Scott GI, Chatterjee S, Zhang Q, Zelinski MB, Xiao S. Wang Y, et al. Among authors: scott gi. Reprod Toxicol. 2020 Apr;93:118-130. doi: 10.1016/j.reprotox.2020.01.009. Epub 2020 Feb 1. Reprod Toxicol. 2020. PMID: 32017985 Free PMC article.
Early microcystin-LR exposure-linked inflammasome activation in mice causes development of fatty liver disease and insulin resistance.
Al-Badrani M, Saha P, Mondal A, Seth RK, Sarkar S, Kimono D, Bose D, Porter DE, Scott GI, Brooks B, Raychoudhury S, Nagarkatti M, Nagarkatti P, Chatterjee S. Al-Badrani M, et al. Among authors: scott gi. Environ Toxicol Pharmacol. 2020 Nov;80:103457. doi: 10.1016/j.etap.2020.103457. Epub 2020 Jul 17. Environ Toxicol Pharmacol. 2020. PMID: 32687983 Free PMC article.
Microcystin exposure worsens nonalcoholic fatty liver disease associated ectopic glomerular toxicity via NOX-2-MIR21 axis.
Sarkar S, Alhasson F, Kimono D, Albadrani M, Seth RK, Xiao S, Porter DE, Scott GI, Brooks B, Nagarkatti M, Nagarkatti P, Chatterjee S. Sarkar S, et al. Among authors: scott gi. Environ Toxicol Pharmacol. 2020 Jan;73:103281. doi: 10.1016/j.etap.2019.103281. Epub 2019 Oct 20. Environ Toxicol Pharmacol. 2020. PMID: 31706246 Free PMC article.
Environmental microcystin targets the microbiome and increases the risk of intestinal inflammatory pathology via NOX2 in underlying murine model of Nonalcoholic Fatty Liver Disease.
Sarkar S, Kimono D, Albadrani M, Seth RK, Busbee P, Alghetaa H, Porter DE, Scott GI, Brooks B, Nagarkatti M, Nagarkatti P, Chatterjee S. Sarkar S, et al. Among authors: scott gi. Sci Rep. 2019 Jun 19;9(1):8742. doi: 10.1038/s41598-019-45009-1. Sci Rep. 2019. PMID: 31217465 Free PMC article.
Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21.
Albadrani M, Seth RK, Sarkar S, Kimono D, Mondal A, Bose D, Porter DE, Scott GI, Brooks B, Raychoudhury S, Nagarkatti M, Nagarkatti P, Jule Y, Diehl AM, Chatterjee S. Albadrani M, et al. Among authors: scott gi. Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G408-G428. doi: 10.1152/ajpgi.00061.2019. Epub 2019 Aug 8. Am J Physiol Gastrointest Liver Physiol. 2019. PMID: 31393787 Free PMC article.
128 results