Scott DO - Search Results

1

Species independence in brain tissue binding using brain homogenates.

Di L, Umland JP, Chang G, Huang Y, Lin Z, Scott DO, Troutman MD, Liston TE. Di L, et al. Among authors: scott do. Drug Metab Dispos. 2011 Jul;39(7):1270-7. doi: 10.1124/dmd.111.038778. Epub 2011 Apr 7. Drug Metab Dispos. 2011. PMID: 21474681

2

In silico modeling of nonspecific binding to human liver microsomes.

Gao H, Yao L, Mathieu HW, Zhang Y, Maurer TS, Troutman MD, Scott DO, Ruggeri RB, Lin J. Gao H, et al. Among authors: scott do. Drug Metab Dispos. 2008 Oct;36(10):2130-5. doi: 10.1124/dmd.107.020131. Epub 2008 Jul 7. Drug Metab Dispos. 2008. PMID: 18606744

3

Strategic use of plasma and microsome binding to exploit in vitro clearance in early drug discovery.

Chang G, Steyn SJ, Umland JP, Scott DO. Chang G, et al. Among authors: scott do. ACS Med Chem Lett. 2010 Feb 3;1(2):50-3. doi: 10.1021/ml900012h. eCollection 2010 May 13. ACS Med Chem Lett. 2010. PMID: 24900175 Free PMC article.

4

Structural attributes influencing unbound tissue distribution.

Orozco CC, Atkinson K, Ryu S, Chang G, Keefer C, Lin J, Riccardi K, Mongillo RK, Tess D, Filipski KJ, Kalgutkar AS, Litchfield J, Scott D, Di L. Orozco CC, et al. Eur J Med Chem. 2020 Jan 1;185:111813. doi: 10.1016/j.ejmech.2019.111813. Epub 2019 Oct 28. Eur J Med Chem. 2020. PMID: 31732255

5

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design.

Di L, Keefer C, Scott DO, Strelevitz TJ, Chang G, Bi YA, Lai Y, Duckworth J, Fenner K, Troutman MD, Obach RS. Di L, et al. Among authors: scott do. Eur J Med Chem. 2012 Nov;57:441-8. doi: 10.1016/j.ejmech.2012.06.043. Epub 2012 Jul 16. Eur J Med Chem. 2012. PMID: 22840492

6

In Vitro-In Vivo Extrapolation of Intestinal Availability for Carboxylesterase Substrates Using Portal Vein-Cannulated Monkey.

Trapa PE, Beaumont K, Atkinson K, Eng H, King-Ahmad A, Scott DO, Maurer TS, Di L. Trapa PE, et al. Among authors: scott do. J Pharm Sci. 2017 Mar;106(3):898-905. doi: 10.1016/j.xphs.2016.12.001. Epub 2016 Dec 18. J Pharm Sci. 2017. PMID: 27998705

7

Passive drug permeation through membranes and cellular distribution.

Scott DO, Ghosh A, Di L, Maurer TS. Scott DO, et al. Pharmacol Res. 2017 Mar;117:94-102. doi: 10.1016/j.phrs.2016.11.028. Epub 2016 Nov 24. Pharmacol Res. 2017. PMID: 27890815 Review.

8

Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice.

Maurer TS, Debartolo DB, Tess DA, Scott DO. Maurer TS, et al. Among authors: scott do. Drug Metab Dispos. 2005 Jan;33(1):175-81. doi: 10.1124/dmd.104.001222. Epub 2004 Oct 22. Drug Metab Dispos. 2005. PMID: 15502010

9

Excretion, metabolism, and pharmacokinetics of CP-945,598, a selective cannabinoid receptor antagonist, in rats, mice, and dogs.

Miao Z, Scott DO, Griffith DA, Day R, Prakash C. Miao Z, et al. Among authors: scott do. Drug Metab Dispos. 2011 Dec;39(12):2191-208. doi: 10.1124/dmd.111.040360. Epub 2011 Aug 29. Drug Metab Dispos. 2011. PMID: 21875952

10

Toward a unified model of passive drug permeation II: the physiochemical determinants of unbound tissue distribution with applications to the design of hepatoselective glucokinase activators.

Ghosh A, Maurer TS, Litchfield J, Varma MV, Rotter C, Scialis R, Feng B, Tu M, Guimaraes CR, Scott DO. Ghosh A, et al. Among authors: scott do. Drug Metab Dispos. 2014 Oct;42(10):1599-610. doi: 10.1124/dmd.114.058032. Epub 2014 Jul 14. Drug Metab Dispos. 2014. PMID: 25024402

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