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Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition.
Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PRE, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Plückthun A. Deluigi M, et al. Among authors: scott dj. Nat Commun. 2022 Jan 19;13(1):382. doi: 10.1038/s41467-021-27911-3. Nat Commun. 2022. PMID: 35046410 Free PMC article.
Stabilizing membrane proteins through protein engineering.
Scott DJ, Kummer L, Tremmel D, Plückthun A. Scott DJ, et al. Curr Opin Chem Biol. 2013 Jun;17(3):427-35. doi: 10.1016/j.cbpa.2013.04.002. Epub 2013 Apr 29. Curr Opin Chem Biol. 2013. PMID: 23639904 Review.
Probing the correlation between ligand efficacy and conformational diversity at the α1A-adrenoreceptor reveals allosteric coupling of its microswitches.
Wu FJ, Williams LM, Abdul-Ridha A, Gunatilaka A, Vaid TM, Kocan M, Whitehead AR, Griffin MDW, Bathgate RAD, Scott DJ, Gooley PR. Wu FJ, et al. Among authors: scott dj. J Biol Chem. 2020 May 22;295(21):7404-7417. doi: 10.1074/jbc.RA120.012842. Epub 2020 Apr 17. J Biol Chem. 2020. PMID: 32303636 Free PMC article.
727 results