Scott DJ - Search Results

1

SYT1-associated neurodevelopmental disorder: a case series.

Baker K, Gordon SL, Melland H, Bumbak F, Scott DJ, Jiang TJ, Owen D, Turner BJ, Boyd SG, Rossi M, Al-Raqad M, Elpeleg O, Peck D, Mancini GMS, Wilke M, Zollino M, Marangi G, Weigand H, Borggraefe I, Haack T, Stark Z, Sadedin S; Broad Center for Mendelian Genomics; Tan TY, Jiang Y, Gibbs RA, Ellingwood S, Amaral M, Kelley W, Kurian MA, Cousin MA, Raymond FL. Baker K, et al. Among authors: scott dj. Brain. 2018 Sep 1;141(9):2576-2591. doi: 10.1093/brain/awy209. Brain. 2018. PMID: 30107533 Free PMC article.

2

Characterisation of a cell-free synthesised G-protein coupled receptor.

Shilling PJ, Bumbak F, Scott DJ, Bathgate RAD, Gooley PR. Shilling PJ, et al. Among authors: scott dj. Sci Rep. 2017 Apr 24;7(1):1094. doi: 10.1038/s41598-017-01227-z. Sci Rep. 2017. PMID: 28439124 Free PMC article.

3

Optimization and ¹³CH₃ methionine labeling of a signaling competent neurotensin receptor 1 variant for NMR studies.

Bumbak F, Keen AC, Gunn NJ, Gooley PR, Bathgate RAD, Scott DJ. Bumbak F, et al. Among authors: scott dj. Biochim Biophys Acta Biomembr. 2018 Jun;1860(6):1372-1383. doi: 10.1016/j.bbamem.2018.03.020. Epub 2018 Mar 26. Biochim Biophys Acta Biomembr. 2018. PMID: 29596791 Free article.

4

Expression and Purification of a Functional E. coli ¹³CH₃-Methionine-Labeled Thermostable Neurotensin Receptor 1 Variant for Solution NMR Studies.

Bumbak F, Bathgate RAD, Scott DJ, Gooley PR. Bumbak F, et al. Among authors: scott dj. Methods Mol Biol. 2019;1947:31-55. doi: 10.1007/978-1-4939-9121-1_3. Methods Mol Biol. 2019. PMID: 30969410

5

Expanding the genotype and phenotype spectrum of SYT1-associated neurodevelopmental disorder.

Melland H, Bumbak F, Kolesnik-Taylor A, Ng-Cordell E, John A, Constantinou P, Joss S, Larsen M, Fagerberg C, Laulund LW, Thies J, Emslie F, Willemsen M, Kleefstra T, Pfundt R, Barrick R, Chang R, Loong L, Alfadhel M, van der Smagt J, Nizon M, Kurian MA, Scott DJ, Ziarek JJ, Gordon SL, Baker K. Melland H, et al. Among authors: scott dj. Genet Med. 2022 Apr;24(4):880-893. doi: 10.1016/j.gim.2021.12.002. Epub 2022 Jan 29. Genet Med. 2022. PMID: 35101335 Free PMC article.

6

Conformational Changes in Tyrosine 11 of Neurotensin Are Required to Activate the Neurotensin Receptor 1.

Bumbak F, Thomas T, Noonan-Williams BJ, Vaid TM, Yan F, Whitehead AR, Bruell S, Kocan M, Tan X, Johnson MA, Bathgate RAD, Chalmers DK, Gooley PR, Scott DJ. Bumbak F, et al. Among authors: scott dj. ACS Pharmacol Transl Sci. 2020 Apr 29;3(4):690-705. doi: 10.1021/acsptsci.0c00026. eCollection 2020 Aug 14. ACS Pharmacol Transl Sci. 2020. PMID: 32832871 Free PMC article.

7

Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS₁).

Bumbak F, Pons M, Inoue A, Paniagua JC, Yan F, Wu H, Robson SA, Bathgate RAD, Scott DJ, Gooley PR, Ziarek JJ. Bumbak F, et al. Among authors: scott dj. Cell Rep. 2023 Jan 31;42(1):112015. doi: 10.1016/j.celrep.2023.112015. Epub 2023 Jan 20. Cell Rep. 2023. PMID: 36680775 Free PMC article.

8

Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314.

Bumbak F, Bower JB, Zemmer SC, Inoue A, Pons M, Paniagua JC, Yan F, Ford J, Wu H, Robson SA, Bathgate RAD, Scott DJ, Gooley PR, Ziarek JJ. Bumbak F, et al. Among authors: scott dj. Nat Commun. 2023 Jun 7;14(1):3328. doi: 10.1038/s41467-023-38894-8. Nat Commun. 2023. PMID: 37286565 Free PMC article.

9

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1.

Sethi A, Bruell S, Patil N, Hossain MA, Scott DJ, Petrie EJ, Bathgate RAD, Gooley PR. Sethi A, et al. Among authors: scott dj. Nat Commun. 2016 Apr 18;7:11344. doi: 10.1038/ncomms11344. Nat Commun. 2016. PMID: 27088579 Free PMC article.

10

Gram scale preparation of clozapine N-oxide (CNO), a synthetic small molecule actuator for muscarinic acetylcholine DREADDs.

van der Peet PL, Gunawan C, Abdul-Ridha A, Ma S, Scott DJ, Gundlach AL, Bathgate RAD, White JM, Williams SJ. van der Peet PL, et al. Among authors: scott dj. MethodsX. 2018 Mar 23;5:257-267. doi: 10.1016/j.mex.2018.03.003. eCollection 2018. MethodsX. 2018. PMID: 30038895 Free PMC article.

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