Scott DA - Search Results

1

Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants.

Avellaneda Matteo D, Wells GA, Luna LA, Grunseth AJ, Zagnitko O, Scott DA, Hoang A, Luthra A, Swairjo MA, Schiffer JM, Sohl CD. Avellaneda Matteo D, et al. Among authors: scott da. Biochem J. 2018 Oct 22;475(20):3221-3238. doi: 10.1042/BCJ20180424. Biochem J. 2018. PMID: 30249606 Free PMC article.

2

Registered report: IDH mutation impairs histone demethylation and results in a block to cell differentiation.

Richarson AD, Scott DA, Zagnitko O, Aza-Blanc P, Chang CC, Russler-Germain DA; Reproducibility Project: Cancer Biology. Richarson AD, et al. Among authors: scott da. Elife. 2016 Mar 11;5:e10860. doi: 10.7554/eLife.10860. Elife. 2016. PMID: 26971564 Free PMC article.

3

Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.

Avellaneda Matteo D, Grunseth AJ, Gonzalez ER, Anselmo SL, Kennedy MA, Moman P, Scott DA, Hoang A, Sohl CD. Avellaneda Matteo D, et al. Among authors: scott da. J Biol Chem. 2017 May 12;292(19):7971-7983. doi: 10.1074/jbc.M117.776179. Epub 2017 Mar 22. J Biol Chem. 2017. PMID: 28330869 Free PMC article.

4

Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression.

Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben AL, Shao M, Zhang F, Xu P, Li Y, Cao H, Zagnitko O, Scott DA, Gupta RK, Xing C, Zhang BB, Lin HV, Scherer PE. Zhu Y, et al. Among authors: scott da. Diabetes. 2017 Nov;66(11):2789-2799. doi: 10.2337/db17-0323. Epub 2017 Sep 6. Diabetes. 2017. PMID: 28877911 Free PMC article.

5

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.

Luna LA, Lesecq Z, White KA, Hoang A, Scott DA, Zagnitko O, Bobkov AA, Barber DL, Schiffer JM, Isom DG, Sohl CD. Luna LA, et al. Among authors: scott da. Biochem J. 2020 Aug 28;477(16):2999-3018. doi: 10.1042/BCJ20200311. Biochem J. 2020. PMID: 32729927 Free PMC article.

6

Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness.

Zhang Y, Recouvreux MV, Jung M, Galenkamp KMO, Li Y, Zagnitko O, Scott DA, Lowy AM, Commisso C. Zhang Y, et al. Among authors: scott da. Cancer Discov. 2021 Jul;11(7):1808-1825. doi: 10.1158/2159-8290.CD-20-0119. Epub 2021 Mar 2. Cancer Discov. 2021. PMID: 33653692 Free PMC article.

7

Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells.

Filipp FV, Scott DA, Ronai ZA, Osterman AL, Smith JW. Filipp FV, et al. Among authors: scott da. Pigment Cell Melanoma Res. 2012 May;25(3):375-83. doi: 10.1111/j.1755-148X.2012.00989.x. Epub 2012 Mar 27. Pigment Cell Melanoma Res. 2012. PMID: 22360810 Free PMC article.

8

Culturable bacteria in the entire acne lesion and short-chain fatty acid metabolites of Cutibacterium acnes and Staphylococcus epidermidis isolates.

Huang TY, Jiang YE, Scott DA. Huang TY, et al. Among authors: scott da. Biochem Biophys Res Commun. 2022 Sep 24;622:45-49. doi: 10.1016/j.bbrc.2022.06.068. Epub 2022 Jun 30. Biochem Biophys Res Commun. 2022. PMID: 35843093 Free article.

9

Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma.

LaGory EL, Wu C, Taniguchi CM, Ding CC, Chi JT, von Eyben R, Scott DA, Richardson AD, Giaccia AJ. LaGory EL, et al. Among authors: scott da. Cell Rep. 2015 Jul 7;12(1):116-127. doi: 10.1016/j.celrep.2015.06.006. Epub 2015 Jun 25. Cell Rep. 2015. PMID: 26119730 Free PMC article.

10

Identification and Characterization of IMD-0354 as a Glutamine Carrier Protein Inhibitor in Melanoma.

Feng Y, Pathria G, Heynen-Genel S, Jackson M, James B, Yin J, Scott DA, Ronai ZA. Feng Y, et al. Among authors: scott da. Mol Cancer Ther. 2021 May;20(5):816-832. doi: 10.1158/1535-7163.MCT-20-0354. Epub 2021 Feb 25. Mol Cancer Ther. 2021. PMID: 33632871 Free PMC article.

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