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Multicenter study using paraffin-embedded tumor tissue testing PITX2 DNA methylation as a marker for outcome prediction in tamoxifen-treated, node-negative breast cancer patients.
Harbeck N, Nimmrich I, Hartmann A, Ross JS, Cufer T, Grützmann R, Kristiansen G, Paradiso A, Hartmann O, Margossian A, Martens J, Schwope I, Lukas A, Müller V, Milde-Langosch K, Nährig J, Foekens J, Maier S, Schmitt M, Lesche R. Harbeck N, et al. Among authors: schwope i. J Clin Oncol. 2008 Nov 1;26(31):5036-42. doi: 10.1200/JCO.2007.14.1697. Epub 2008 Aug 18. J Clin Oncol. 2008. PMID: 18711169
DNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients--Technical and clinical validation in a multi-centre setting in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group.
Maier S, Nimmrich I, Koenig T, Eppenberger-Castori S, Bohlmann I, Paradiso A, Spyratos F, Thomssen C, Mueller V, Nährig J, Schittulli F, Kates R, Lesche R, Schwope I, Kluth A, Marx A, Martens JW, Foekens JA, Schmitt M, Harbeck N; European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group. Maier S, et al. Among authors: schwope i. Eur J Cancer. 2007 Jul;43(11):1679-86. doi: 10.1016/j.ejca.2007.04.025. Epub 2007 Jun 29. Eur J Cancer. 2007. PMID: 17601725
DNA hypermethylation of PITX2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients.
Nimmrich I, Sieuwerts AM, Meijer-van Gelder ME, Schwope I, Bolt-de Vries J, Harbeck N, Koenig T, Hartmann O, Kluth A, Dietrich D, Magdolen V, Portengen H, Look MP, Klijn JG, Lesche R, Schmitt M, Maier S, Foekens JA, Martens JW. Nimmrich I, et al. Among authors: schwope i. Breast Cancer Res Treat. 2008 Oct;111(3):429-37. doi: 10.1007/s10549-007-9800-8. Epub 2007 Oct 28. Breast Cancer Res Treat. 2008. PMID: 17965955
Tumour class prediction and discovery by microarray-based DNA methylation analysis.
Adorján P, Distler J, Lipscher E, Model F, Müller J, Pelet C, Braun A, Florl AR, Gütig D, Grabs G, Howe A, Kursar M, Lesche R, Leu E, Lewin A, Maier S, Müller V, Otto T, Scholz C, Schulz WA, Seifert HH, Schwope I, Ziebarth H, Berlin K, Piepenbrock C, Olek A. Adorján P, et al. Among authors: schwope i. Nucleic Acids Res. 2002 Mar 1;30(5):e21. doi: 10.1093/nar/30.5.e21. Nucleic Acids Res. 2002. PMID: 11861926 Free PMC article.
A real-time PCR assay for DNA-methylation using methylation-specific blockers.
Cottrell SE, Distler J, Goodman NS, Mooney SH, Kluth A, Olek A, Schwope I, Tetzner R, Ziebarth H, Berlin K. Cottrell SE, et al. Among authors: schwope i. Nucleic Acids Res. 2004 Jan 13;32(1):e10. doi: 10.1093/nar/gnh008. Nucleic Acids Res. 2004. PMID: 14722226 Free PMC article.
Synthesis of 3',5'-Dipeptidyl Oligonucleotides.
Schwope I, Bleczinski CF, Richert C. Schwope I, et al. J Org Chem. 1999 Jun 25;64(13):4749-4761. doi: 10.1021/jo990036d. J Org Chem. 1999. PMID: 11674548