Schwochert JA - Search Results

1

DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2-p53 Inhibitor.

Silvestri AP, Zhang Q, Ping Y, Muir EW, Zhao J, Chakka SK, Wang G, Bray WM, Chen W, Fribourgh JL, Tripathi S, He Y, Rubin SM, Satz AL, Pye CR, Kuai L, Su W, Schwochert JA. Silvestri AP, et al. Among authors: schwochert ja. ACS Med Chem Lett. 2023 May 5;14(6):820-826. doi: 10.1021/acsmedchemlett.3c00117. eCollection 2023 Jun 8. ACS Med Chem Lett. 2023. PMID: 37312849

2

Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues.

Bockus AT, Schwochert JA, Pye CR, Townsend CE, Sok V, Bednarek MA, Lokey RS. Bockus AT, et al. Among authors: schwochert ja. J Med Chem. 2015 Sep 24;58(18):7409-18. doi: 10.1021/acs.jmedchem.5b00919. Epub 2015 Sep 2. J Med Chem. 2015. PMID: 26308180

3

Stereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides.

Schwochert J, Lao Y, Pye CR, Naylor MR, Desai PV, Gonzalez Valcarcel IC, Barrett JA, Sawada G, Blanco MJ, Lokey RS. Schwochert J, et al. ACS Med Chem Lett. 2016 Jun 6;7(8):757-61. doi: 10.1021/acsmedchemlett.6b00100. eCollection 2016 Aug 11. ACS Med Chem Lett. 2016. PMID: 27563399 Free PMC article.

4

Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry.

Furukawa A, Townsend CE, Schwochert J, Pye CR, Bednarek MA, Lokey RS. Furukawa A, et al. J Med Chem. 2016 Oct 27;59(20):9503-9512. doi: 10.1021/acs.jmedchem.6b01246. Epub 2016 Oct 11. J Med Chem. 2016. PMID: 27690434

5

Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules.

Pye CR, Hewitt WM, Schwochert J, Haddad TD, Townsend CE, Etienne L, Lao Y, Limberakis C, Furukawa A, Mathiowetz AM, Price DA, Liras S, Lokey RS. Pye CR, et al. J Med Chem. 2017 Mar 9;60(5):1665-1672. doi: 10.1021/acs.jmedchem.6b01483. Epub 2017 Jan 25. J Med Chem. 2017. PMID: 28059508 Free PMC article.

6

Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products.

Bockus AT, Lexa KW, Pye CR, Kalgutkar AS, Gardner JW, Hund KC, Hewitt WM, Schwochert JA, Glassey E, Price DA, Mathiowetz AM, Liras S, Jacobson MP, Lokey RS. Bockus AT, et al. Among authors: schwochert ja. J Med Chem. 2015 Jun 11;58(11):4581-9. doi: 10.1021/acs.jmedchem.5b00128. Epub 2015 May 20. J Med Chem. 2015. PMID: 25950816

7

CycLS: Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry.

Townsend C, Furukawa A, Schwochert J, Pye CR, Edmondson Q, Lokey RS. Townsend C, et al. Bioorg Med Chem. 2018 Mar 15;26(6):1232-1238. doi: 10.1016/j.bmc.2018.01.027. Epub 2018 Feb 3. Bioorg Med Chem. 2018. PMID: 29459147

8

Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility.

Naylor MR, Ly AM, Handford MJ, Ramos DP, Pye CR, Furukawa A, Klein VG, Noland RP, Edmondson Q, Turmon AC, Hewitt WM, Schwochert J, Townsend CE, Kelly CN, Blanco MJ, Lokey RS. Naylor MR, et al. J Med Chem. 2018 Dec 27;61(24):11169-11182. doi: 10.1021/acs.jmedchem.8b01259. Epub 2018 Dec 11. J Med Chem. 2018. PMID: 30395703

9

Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability.

Kelly CN, Townsend CE, Jain AN, Naylor MR, Pye CR, Schwochert J, Lokey RS. Kelly CN, et al. J Am Chem Soc. 2021 Jan 20;143(2):705-714. doi: 10.1021/jacs.0c06115. Epub 2020 Dec 31. J Am Chem Soc. 2021. PMID: 33381960 Free PMC article.

10

Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives.

Klein VG, Bray WM, Wang HY, Edmondson Q, Schwochert J, Ono S, Naylor MR, Turmon AC, Faris JH, Okada O, Taunton J, Lokey RS. Klein VG, et al. ACS Chem Biol. 2021 Aug 20;16(8):1354-1364. doi: 10.1021/acschembio.1c00094. Epub 2021 Jul 12. ACS Chem Biol. 2021. PMID: 34251165 Free PMC article.

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