Schwochert J - Search Results

1

Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives.

Klein VG, Bray WM, Wang HY, Edmondson Q, Schwochert J, Ono S, Naylor MR, Turmon AC, Faris JH, Okada O, Taunton J, Lokey RS. Klein VG, et al. Among authors: schwochert j. ACS Chem Biol. 2021 Aug 20;16(8):1354-1364. doi: 10.1021/acschembio.1c00094. Epub 2021 Jul 12. ACS Chem Biol. 2021. PMID: 34251165 Free PMC article.

2

Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides.

Schwochert J, Pye C, Ahlbach C, Abdollahian Y, Farley K, Khunte B, Limberakis C, Kalgutkar AS, Eng H, Shapiro MJ, Mathiowetz AM, Price DA, Liras S, Lokey RS. Schwochert J, et al. Org Lett. 2014 Dec 5;16(23):6088-91. doi: 10.1021/ol503170b. Epub 2014 Nov 20. Org Lett. 2014. PMID: 25412436

3

Biosynthetic products from a nearshore-derived gram-negative bacterium enable reassessment of the kailuin depsipeptides.

Theodore CM, Lorig-Roach N, Still PC, Johnson TA, Drašković M, Schwochert JA, Naphen CN, Crews MS, Barker SA, Valeriote FA, Lokey RS, Crews P. Theodore CM, et al. J Nat Prod. 2015 Mar 27;78(3):441-52. doi: 10.1021/np500840n. Epub 2015 Feb 20. J Nat Prod. 2015. PMID: 25699470 Free PMC article.

4

Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products.

Bockus AT, Lexa KW, Pye CR, Kalgutkar AS, Gardner JW, Hund KC, Hewitt WM, Schwochert JA, Glassey E, Price DA, Mathiowetz AM, Liras S, Jacobson MP, Lokey RS. Bockus AT, et al. J Med Chem. 2015 Jun 11;58(11):4581-9. doi: 10.1021/acs.jmedchem.5b00128. Epub 2015 May 20. J Med Chem. 2015. PMID: 25950816

5

Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides.

Schwochert J, Turner R, Thang M, Berkeley RF, Ponkey AR, Rodriguez KM, Leung SS, Khunte B, Goetz G, Limberakis C, Kalgutkar AS, Eng H, Shapiro MJ, Mathiowetz AM, Price DA, Liras S, Jacobson MP, Lokey RS. Schwochert J, et al. Org Lett. 2015 Jun 19;17(12):2928-31. doi: 10.1021/acs.orglett.5b01162. Epub 2015 Jun 5. Org Lett. 2015. PMID: 26046483

6

Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues.

Bockus AT, Schwochert JA, Pye CR, Townsend CE, Sok V, Bednarek MA, Lokey RS. Bockus AT, et al. J Med Chem. 2015 Sep 24;58(18):7409-18. doi: 10.1021/acs.jmedchem.5b00919. Epub 2015 Sep 2. J Med Chem. 2015. PMID: 26308180

7

Stereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides.

Schwochert J, Lao Y, Pye CR, Naylor MR, Desai PV, Gonzalez Valcarcel IC, Barrett JA, Sawada G, Blanco MJ, Lokey RS. Schwochert J, et al. ACS Med Chem Lett. 2016 Jun 6;7(8):757-61. doi: 10.1021/acsmedchemlett.6b00100. eCollection 2016 Aug 11. ACS Med Chem Lett. 2016. PMID: 27563399 Free PMC article.

8

Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry.

Furukawa A, Townsend CE, Schwochert J, Pye CR, Bednarek MA, Lokey RS. Furukawa A, et al. Among authors: schwochert j. J Med Chem. 2016 Oct 27;59(20):9503-9512. doi: 10.1021/acs.jmedchem.6b01246. Epub 2016 Oct 11. J Med Chem. 2016. PMID: 27690434

9

Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules.

Pye CR, Hewitt WM, Schwochert J, Haddad TD, Townsend CE, Etienne L, Lao Y, Limberakis C, Furukawa A, Mathiowetz AM, Price DA, Liras S, Lokey RS. Pye CR, et al. Among authors: schwochert j. J Med Chem. 2017 Mar 9;60(5):1665-1672. doi: 10.1021/acs.jmedchem.6b01483. Epub 2017 Jan 25. J Med Chem. 2017. PMID: 28059508 Free PMC article.

10

CycLS: Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry.

Townsend C, Furukawa A, Schwochert J, Pye CR, Edmondson Q, Lokey RS. Townsend C, et al. Among authors: schwochert j. Bioorg Med Chem. 2018 Mar 15;26(6):1232-1238. doi: 10.1016/j.bmc.2018.01.027. Epub 2018 Feb 3. Bioorg Med Chem. 2018. PMID: 29459147

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