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An internal thioester in a pathogen surface protein mediates covalent host binding.
Walden M, Edwards JM, Dziewulska AM, Bergmann R, Saalbach G, Kan SY, Miller OK, Weckener M, Jackson RJ, Shirran SL, Botting CH, Florence GJ, Rohde M, Banfield MJ, Schwarz-Linek U. Walden M, et al. Among authors: schwarz linek u. Elife. 2015 Jun 2;4:e06638. doi: 10.7554/eLife.06638. Elife. 2015. PMID: 26032562 Free PMC article.
Insights into the Mechanism of the Cyanobactin Heterocyclase Enzyme.
Ge Y, Czekster CM, Miller OK, Botting CH, Schwarz-Linek U, Naismith JH. Ge Y, et al. Among authors: schwarz linek u. Biochemistry. 2019 Apr 23;58(16):2125-2132. doi: 10.1021/acs.biochem.9b00084. Epub 2019 Apr 5. Biochemistry. 2019. PMID: 30912640 Free PMC article.
The cyanobactin heterocyclase enzyme: a processive adenylase that operates with a defined order of reaction.
Koehnke J, Bent AF, Zollman D, Smith K, Houssen WE, Zhu X, Mann G, Lebl T, Scharff R, Shirran S, Botting CH, Jaspars M, Schwarz-Linek U, Naismith JH. Koehnke J, et al. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):13991-6. doi: 10.1002/anie.201306302. Epub 2013 Nov 8. Angew Chem Int Ed Engl. 2013. PMID: 24214017 Free PMC article. No abstract available.
The Scottish Structural Proteomics Facility: targets, methods and outputs.
Oke M, Carter LG, Johnson KA, Liu H, McMahon SA, Yan X, Kerou M, Weikart ND, Kadi N, Sheikh MA, Schmelz S, Dorward M, Zawadzki M, Cozens C, Falconer H, Powers H, Overton IM, van Niekerk CA, Peng X, Patel P, Garrett RA, Prangishvili D, Botting CH, Coote PJ, Dryden DT, Barton GJ, Schwarz-Linek U, Challis GL, Taylor GL, White MF, Naismith JH. Oke M, et al. J Struct Funct Genomics. 2010 Jun;11(2):167-80. doi: 10.1007/s10969-010-9090-y. Epub 2010 Apr 24. J Struct Funct Genomics. 2010. PMID: 20419351 Free PMC article.
An efficient method for the in vitro production of azol(in)e-based cyclic peptides.
Houssen WE, Bent AF, McEwan AR, Pieiller N, Tabudravu J, Koehnke J, Mann G, Adaba RI, Thomas L, Hawas UW, Liu H, Schwarz-Linek U, Smith MC, Naismith JH, Jaspars M. Houssen WE, et al. Among authors: schwarz linek u. Angew Chem Int Ed Engl. 2014 Dec 15;53(51):14171-4. doi: 10.1002/anie.201408082. Epub 2014 Oct 21. Angew Chem Int Ed Engl. 2014. PMID: 25331823 Free PMC article.
32 results