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Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies.
Braz J Med Biol Res. 2016 Dec 12;49(12):e5646. doi: 10.1590/1414-431X20165646.
Braz J Med Biol Res. 2016.
PMID: 27982281
Free PMC article.
Review.
Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies.
Andrade EL, Bento AF, Cavalli J, Oliveira SK, Freitas CS, Marcon R, Schwanke RC, Siqueira JM, Calixto JB.
Andrade EL, et al. Among authors: schwanke rc.
Braz J Med Biol Res. 2016 Oct 24;49(11):e5644. doi: 10.1590/1414-431X20165644.
Braz J Med Biol Res. 2016.
PMID: 27783811
Free PMC article.
Review.
Item in Clipboard
EPA- and DHA-derived resolvins' actions in inflammatory bowel disease.
Schwanke RC, Marcon R, Bento AF, Calixto JB.
Schwanke RC, et al.
Eur J Pharmacol. 2016 Aug 15;785:156-164. doi: 10.1016/j.ejphar.2015.08.050. Epub 2015 Aug 29.
Eur J Pharmacol. 2016.
PMID: 26325092
Free article.
Review.
Item in Clipboard
Oral administration of the flavonoid myricitrin prevents dextran sulfate sodium-induced experimental colitis in mice through modulation of PI3K/Akt signaling pathway.
Schwanke RC, Marcon R, Meotti FC, Bento AF, Dutra RC, Pizzollatti MG, Calixto JB.
Schwanke RC, et al.
Mol Nutr Food Res. 2013 Nov;57(11):1938-49. doi: 10.1002/mnfr.201300134. Epub 2013 Jul 17.
Mol Nutr Food Res. 2013.
PMID: 23861337
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A new series of acetohydroxamates shows in vitro and in vivo anticancer activity against melanoma.
Segat GC, Moreira CG, Santos EC, Heller M, Schwanke RC, Aksenov AV, Aksenov NA, Aksenov DA, Kornienko A, Marcon R, Calixto JB.
Segat GC, et al. Among authors: schwanke rc.
Invest New Drugs. 2020 Aug;38(4):977-989. doi: 10.1007/s10637-019-00849-6. Epub 2019 Sep 6.
Invest New Drugs. 2020.
PMID: 31493129
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Molecular cloning, expression in Escherichia coli and production of bioactive homogeneous recombinant human granulocyte and macrophage colony stimulating factor.
Schwanke RC, Renard G, Chies JM, Campos MM, Batista EL Jr, Santos DS, Basso LA.
Schwanke RC, et al.
Int J Biol Macromol. 2009 Aug 1;45(2):97-102. doi: 10.1016/j.ijbiomac.2009.04.005. Epub 2009 Apr 21.
Int J Biol Macromol. 2009.
PMID: 19389424
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