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The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver.
Mederacke I, Filliol A, Affo S, Nair A, Hernandez C, Sun Q, Hamberger F, Brundu F, Chen Y, Ravichandra A, Huebener P, Anke H, Shi H, Martínez García de la Torre RA, Smith JR, Henderson NC, Vondran FWR, Rothlin CV, Baehre H, Tabas I, Sancho-Bru P, Schwabe RF. Mederacke I, et al. Among authors: schwabe rf. Sci Transl Med. 2022 Apr 6;14(639):eabe5795. doi: 10.1126/scitranslmed.abe5795. Epub 2022 Apr 6. Sci Transl Med. 2022. PMID: 35385339 Free PMC article.
Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis.
Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R, Brenner DA, Tabas I. Li Y, et al. Among authors: schwabe rf. J Biol Chem. 2005 Jun 10;280(23):21763-72. doi: 10.1074/jbc.M501759200. Epub 2005 Apr 11. J Biol Chem. 2005. PMID: 15826936 Free article.
Toll-like receptor 4 and hepatic fibrogenesis.
Pradere JP, Troeger JS, Dapito DH, Mencin AA, Schwabe RF. Pradere JP, et al. Among authors: schwabe rf. Semin Liver Dis. 2010 Aug;30(3):232-44. doi: 10.1055/s-0030-1255353. Epub 2010 Jul 21. Semin Liver Dis. 2010. PMID: 20665376 Free PMC article. Review.
Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis.
Affò S, Dominguez M, Lozano JJ, Sancho-Bru P, Rodrigo-Torres D, Morales-Ibanez O, Moreno M, Millán C, Loaeza-del-Castillo A, Altamirano J, García-Pagán JC, Arroyo V, Ginès P, Caballería J, Schwabe RF, Bataller R. Affò S, et al. Among authors: schwabe rf. Gut. 2013 Mar;62(3):452-60. doi: 10.1136/gutjnl-2011-301146. Epub 2012 May 25. Gut. 2013. PMID: 22637703 Free PMC article.
Deactivation of hepatic stellate cells during liver fibrosis resolution in mice.
Troeger JS, Mederacke I, Gwak GY, Dapito DH, Mu X, Hsu CC, Pradere JP, Friedman RA, Schwabe RF. Troeger JS, et al. Among authors: schwabe rf. Gastroenterology. 2012 Oct;143(4):1073-83.e22. doi: 10.1053/j.gastro.2012.06.036. Epub 2012 Jun 27. Gastroenterology. 2012. PMID: 22750464 Free PMC article.
Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice.
Pradere JP, Kluwe J, De Minicis S, Jiao JJ, Gwak GY, Dapito DH, Jang MK, Guenther ND, Mederacke I, Friedman R, Dragomir AC, Aloman C, Schwabe RF. Pradere JP, et al. Among authors: schwabe rf. Hepatology. 2013 Oct;58(4):1461-73. doi: 10.1002/hep.26429. Epub 2013 Aug 9. Hepatology. 2013. PMID: 23553591 Free PMC article.
CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis.
Affò S, Morales-Ibanez O, Rodrigo-Torres D, Altamirano J, Blaya D, Dapito DH, Millán C, Coll M, Caviglia JM, Arroyo V, Caballería J, Schwabe RF, Ginès P, Bataller R, Sancho-Bru P. Affò S, et al. Among authors: schwabe rf. Gut. 2014 Nov;63(11):1782-92. doi: 10.1136/gutjnl-2013-306098. Epub 2014 Jan 10. Gut. 2014. PMID: 24415562 Free PMC article.
170 results