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Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase.
Schaible AM, Filosa R, Temml V, Krauth V, Matteis M, Peduto A, Bruno F, Luderer S, Roviezzo F, Di Mola A, de Rosa M, D'Agostino B, Weinigel C, Barz D, Koeberle A, Pergola C, Schuster D, Werz O. Schaible AM, et al. Among authors: schuster d, d agostino b. Br J Pharmacol. 2014 May;171(9):2399-412. doi: 10.1111/bph.12592. Br J Pharmacol. 2014. PMID: 24467325 Free PMC article.
Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.
Vuorinen A, Engeli RT, Leugger S, Bachmann F, Akram M, Atanasov AG, Waltenberger B, Temml V, Stuppner H, Krenn L, Ateba SB, Njamen D, Davis RA, Odermatt A, Schuster D. Vuorinen A, et al. Among authors: schuster d. J Nat Prod. 2017 Apr 28;80(4):965-974. doi: 10.1021/acs.jnatprod.6b00950. Epub 2017 Mar 20. J Nat Prod. 2017. PMID: 28319389 Free PMC article.
Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.
Garscha U, Romp E, Pace S, Rossi A, Temml V, Schuster D, König S, Gerstmeier J, Liening S, Werner M, Atze H, Wittmann S, Weinigel C, Rummler S, Scriba GK, Sautebin L, Werz O. Garscha U, et al. Among authors: schuster d. Sci Rep. 2017 Aug 24;7(1):9398. doi: 10.1038/s41598-017-09795-w. Sci Rep. 2017. PMID: 28839250 Free PMC article.
Prenylated Stilbenoids Affect Inflammation by Inhibiting the NF-κB/AP-1 Signaling Pathway and Cyclooxygenases and Lipoxygenase.
Hošek J, Leláková V, Bobál P, Pížová H, Gazdová M, Malaník M, Jakubczyk K, Veselý O, Landa P, Temml V, Schuster D, Prachyawarakorn V, Pailee P, Ren G, Zpurný F, Oravec M, Šmejkal K. Hošek J, et al. Among authors: schuster d. J Nat Prod. 2019 Jul 26;82(7):1839-1848. doi: 10.1021/acs.jnatprod.9b00081. Epub 2019 Jul 3. J Nat Prod. 2019. PMID: 31268709
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.
Neukirch K, Alsabil K, Dinh CP, Bilancia R, Raasch M, Ville A, Cerqua I, Viault G, Bréard D, Pace S, Temml V, Brunner E, Jordan PM, Marques MC, Loeser K, Gollowitzer A, Permann S, Gerstmeier J, Lorkowski S, Stuppner H, Garscha U, Rodrigues T, Bernardes GJL, Schuster D, Séraphin D, Richomme P, Rossi A, Mosig AS, Roviezzo F, Werz O, Helesbeux JJ, Koeberle A. Neukirch K, et al. Among authors: schuster d. J Med Chem. 2021 Aug 12;64(15):11496-11526. doi: 10.1021/acs.jmedchem.1c00806. Epub 2021 Jul 19. J Med Chem. 2021. PMID: 34279935 Free PMC article.
891 results