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Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs.
Choi J, Wagner LJS, Timmermans SBPE, Malaker SA, Schumann B, Gray MA, Debets MF, Takashima M, Gehring J, Bertozzi CR. Choi J, et al. Among authors: schumann b. J Am Chem Soc. 2019 Aug 28;141(34):13442-13453. doi: 10.1021/jacs.9b04695. Epub 2019 Aug 16. J Am Chem Soc. 2019. PMID: 31373799 Free PMC article.
Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation.
Debets MF, Tastan OY, Wisnovsky SP, Malaker SA, Angelis N, Moeckl LKR, Choi J, Flynn H, Wagner LJS, Bineva-Todd G, Antonopoulos A, Cioce A, Browne WM, Li Z, Briggs DC, Douglas HL, Hess GT, Agbay AJ, Roustan C, Kjaer S, Haslam SM, Snijders AP, Bassik MC, Moerner WE, Li VSW, Bertozzi CR, Schumann B. Debets MF, et al. Among authors: schumann b. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25293-25301. doi: 10.1073/pnas.2007297117. Epub 2020 Sep 28. Proc Natl Acad Sci U S A. 2020. PMID: 32989128 Free PMC article.
Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase.
Cioce A, Bineva-Todd G, Agbay AJ, Choi J, Wood TM, Debets MF, Browne WM, Douglas HL, Roustan C, Tastan OY, Kjaer S, Bush JT, Bertozzi CR, Schumann B. Cioce A, et al. Among authors: schumann b. ACS Chem Biol. 2021 Oct 15;16(10):1961-1967. doi: 10.1021/acschembio.1c00034. Epub 2021 Apr 9. ACS Chem Biol. 2021. PMID: 33835779 Free PMC article.
4-Deoxy-4-fluoro-GalNAz (4FGalNAz) Is a Metabolic Chemical Reporter of O-GlcNAc Modifications, Highlighting the Notable Substrate Flexibility of O-GlcNAc Transferase.
Jackson EG, Cutolo G, Yang B, Yarravarapu N, Burns MWN, Bineva-Todd G, Roustan C, Thoden JB, Lin-Jones HM, van Kuppevelt TH, Holden HM, Schumann B, Kohler JJ, Woo CM, Pratt MR. Jackson EG, et al. Among authors: schumann b. ACS Chem Biol. 2022 Jan 21;17(1):159-170. doi: 10.1021/acschembio.1c00818. Epub 2021 Dec 21. ACS Chem Biol. 2022. PMID: 34931806 Free PMC article.
Cell-specific bioorthogonal tagging of glycoproteins.
Cioce A, Calle B, Rizou T, Lowery SC, Bridgeman VL, Mahoney KE, Marchesi A, Bineva-Todd G, Flynn H, Li Z, Tastan OY, Roustan C, Soro-Barrio P, Rafiee MR, Garza-Garcia A, Antonopoulos A, Wood TM, Keenan T, Both P, Huang K, Parmeggian F, Snijders AP, Skehel M, Kjær S, Fascione MA, Bertozzi CR, Haslam SM, Flitsch SL, Malaker SA, Malanchi I, Schumann B. Cioce A, et al. Among authors: schumann b. Nat Commun. 2022 Oct 25;13(1):6237. doi: 10.1038/s41467-022-33854-0. Nat Commun. 2022. PMID: 36284108 Free PMC article.
Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth.
Scott E, Hodgson K, Calle B, Turner H, Cheung K, Bermudez A, Marques FJG, Pye H, Yo EC, Islam K, Oo HZ, McClurg UL, Wilson L, Thomas H, Frame FM, Orozco-Moreno M, Bastian K, Arredondo HM, Roustan C, Gray MA, Kelly L, Tolson A, Mellor E, Hysenaj G, Goode EA, Garnham R, Duxfield A, Heavey S, Stopka-Farooqui U, Haider A, Freeman A, Singh S, Johnston EW, Punwani S, Knight B, McCullagh P, McGrath J, Crundwell M, Harries L, Bogdan D, Westaby D, Fowler G, Flohr P, Yuan W, Sharp A, de Bono J, Maitland NJ, Wisnovsky S, Bertozzi CR, Heer R, Guerrero RH, Daugaard M, Leivo J, Whitaker H, Pitteri S, Wang N, Elliott DJ, Schumann B, Munkley J. Scott E, et al. Among authors: schumann b. Oncogene. 2023 Mar;42(12):926-937. doi: 10.1038/s41388-023-02604-x. Epub 2023 Feb 1. Oncogene. 2023. PMID: 36725887 Free PMC article.
O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern.
Gonzalez-Rodriguez E, Zol-Hanlon M, Bineva-Todd G, Marchesi A, Skehel M, Mahoney KE, Roustan C, Borg A, Di Vagno L, Kjær S, Wrobel AG, Benton DJ, Nawrath P, Flitsch SL, Joshi D, González-Ramírez AM, Wilkinson KA, Wilkinson RJ, Wall EC, Hurtado-Guerrero R, Malaker SA, Schumann B. Gonzalez-Rodriguez E, et al. Among authors: schumann b. ACS Cent Sci. 2023 Feb 16;9(3):393-404. doi: 10.1021/acscentsci.2c01349. eCollection 2023 Mar 22. ACS Cent Sci. 2023. PMID: 36968546 Free PMC article.
136 results